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Comment
. 2021 Dec 10;374(6573):1318-1319.
doi: 10.1126/science.abm7949. Epub 2021 Dec 9.

A lipid primes the final cut in dividing cells

Julie A Brill  1   2 , Andrew Wilde  2   3
Affiliations
Comment

A lipid primes the final cut in dividing cells

Julie A Brill et al. Science. .

Abstract

A newly described pathway activates separation of lens cells at the end of cytokinesis.

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  • PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
    Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Gulluni F, et al. Science. 2021 Dec 10;374(6573):eabk0410. doi: 10.1126/science.abk0410. Epub 2021 Dec 10. Science. 2021. PMID: 34882480 Free PMC article.

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