Comparative Study
Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses
- PMID: 3488265
- PMCID: PMC1453105
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Comparative Study
Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses
Immunology.
1986 Aug.
Abstract
Intraepithelial lymphocytes (IEL) were isolated from the small intestine of pigs. They showed a strong blastogenic response to the T-cell mitogens phytohaemagglutinin A (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM); in contrast, mouse IEL responded weakly to these mitogens. The response of pig IEL was age-dependent, reaching adult levels by 9 weeks of age. Early weaning of pigs delayed the onset of this response. The effects of inflammatory mediators on the response of mouse IEL were also examined.
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