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Comparative Study
. 1986 Aug;58(4):621-5.

Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses

A D Wilson, C R Stokes, F J Bourne
Comparative Study

Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses

A D Wilson et al. Immunology. 1986 Aug.

Abstract

Intraepithelial lymphocytes (IEL) were isolated from the small intestine of pigs. They showed a strong blastogenic response to the T-cell mitogens phytohaemagglutinin A (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM); in contrast, mouse IEL responded weakly to these mitogens. The response of pig IEL was age-dependent, reaching adult levels by 9 weeks of age. Early weaning of pigs delayed the onset of this response. The effects of inflammatory mediators on the response of mouse IEL were also examined.

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