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doi: 10.1016/j.chom.2021.11.007.
Compensating P. falciparum artemisinin resistance
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- PMID: 34883062
- DOI: 10.1016/j.chom.2021.11.007
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Compensating P. falciparum artemisinin resistance
Cell Host Microbe.
.
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Abstract
Amino acid deprivation from reduced hemoglobin degradation in Pfkelch13 artemisinin-resistant parasites reduces fitness. In this issue of Cell Host & Microbe, Mesén-Ramírez et al. decipher the role of nutrient permeable channel activity within the parasitophorous vacuolar membrane to compensate for this fitness cost in asexual blood-stage Plasmodium falciparum parasites.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost.Cell Host Microbe. 2021 Dec 8;29(12):1774-1787.e9. doi: 10.1016/j.chom.2021.11.002. Epub 2021 Dec 3. Cell Host Microbe. 2021. PMID: 34863371
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