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. 2021 Dec 2;26(23):7311.
doi: 10.3390/molecules26237311.

Constituents from the Fruiting Bodies of Trametes cubensis and Trametes suaveolens in Vietnam and Their Anti-Inflammatory Bioactivity

Yue-Chiun Li  1 , Nguyen Thi Ngan  2 , Kun-Ching Cheng  3 , Tsong-Long Hwang  4   5   6 , Tran Dinh Thang  2 , Nguyen Ngoc Tuan  2 , Mei-Lin Yang  1 , Ping-Chung Kuo  1 , Tian-Shung Wu  1
Affiliations

Constituents from the Fruiting Bodies of Trametes cubensis and Trametes suaveolens in Vietnam and Their Anti-Inflammatory Bioactivity

Yue-Chiun Li et al. Molecules. .

Abstract

It is reported that various fungi have been used for medicine and edible foods. The tropical Trametes genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi T. cubensis and T. suaveolens were collected in Vietnam. The preliminary bioactivity screening data indicated that the methanol extracts of the fruiting bodies of T. cubensis and T. suaveolens displayed significant inhibition of superoxide anion generation and elastase release in human neutrophils. Therefore, the isolation and characterization were performed on these two species by a combination of chromatographic methods and spectrometric analysis. In total, twenty-four compounds were identified, and among these (1-3) were characterized by 1D-, 2D-NMR, and HRMS analytical data. In addition, the anti-inflammatory potentials of some purified compounds were examined by the cellular model for the inhibition of superoxide anion generation and elastase release in human neutrophils. Among the isolated compounds, (5,14), and (19) displayed significant anti-inflammatory potential. As the results suggest, the extracts and isolated compounds from T. cubensis and T. suaveolens are potential candidates for the further development of new anti-inflammatory lead drugs or natural healthy foods.

Keywords: Trametes cubensis; Trametes suaveolens; anti-inflammatory; elastase release; superoxide anion generation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Fruiting bodies of (a) T. cubensis and (b) T. suaveolens.
Figure 2
Figure 2
Structures and key HMBC correlations (→) of compounds 1–3.
Figure 3
Figure 3
Key NOESY correlations (↔) of compounds 1–3.
Figure 4
Figure 4
Chemical structures of 5, 14, and 19.
Figure 5
Figure 5
In silico modeling of (A) LY294002, (B) 5, (C) 14, and (D) 19 docking into the human neutrophil elastase.
Figure 5
Figure 5
In silico modeling of (A) LY294002, (B) 5, (C) 14, and (D) 19 docking into the human neutrophil elastase.
See this image and copyright information in PMC

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