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. 2021 Nov 24;18(23):12338.
doi: 10.3390/ijerph182312338.

Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review

Jolanta Dadonienė  1   2 , Greta Charukevič  2 , Gabija Jasionytė  3 , Karolina Staškuvienė  3 , Dalia Miltinienė  1   3
Affiliations

Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review

Jolanta Dadonienė et al. Int J Environ Res Public Health. .

Abstract

Despite significant improvement in survival, rheumatic diseases (RD) are associated with premature mortality rates comparable to cardiovascular and neoplastic disorders. The aim of our study was to assess mortality, causes of death, and life expectancy in an inflammatory RD retrospective cohort and compare those with the general population as well as with the results of previously published studies in a systematic literature review. Patients with the first-time diagnosis of inflammatory RD during 2012-2019 were identified and cross-checked for their vital status and the date of death. Sex- and age-standardized mortality ratios (SMR) as well as life expectancy for patients with inflammatory RDs were calculated. The results of a systematic literature review were included in meta-standardized mortality ratio calculations. 11,636 patients with newly diagnosed RD were identified. During a total of 43,064.34 person-years of follow-up, 950 death cases occurred. The prevailing causes of death for the total cohort were cardiovascular diseases and neoplasms. The age- and sex-adjusted SMR for the total cohort was calculated to be 1.32 (1.23; 1.40). Patients with rheumatoid arthritis if diagnosed at age 18-19 tend to live for 1.63 years less than the general population, patients with spondyloarthritis-for 2.7 years less, patients with connective tissue diseases-for almost nine years less than the general population. The findings of our study support the hypothesis that patients with RD have a higher risk of mortality and lower life expectancy than the general population.

Keywords: life expectancy; mortality; rheumatic diseases; standardized mortality ratio; systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Details of study methodology.
Figure 2
Figure 2
Life expectancy of general population, rheumatoid arthritis (RA) patients, spondyloarthritis (SpA) (including psoriatic arthritis and ankylosing spondylitis), and connective tissue diseases (CTD) patients.
See this image and copyright information in PMC

References

    1. Pincus T., Sokka T. Mortality in rheumatic diseases: Introduction. Clin. Exp. Rheumatol. 2008;26:S1–S4. - PubMed
    1. Mok C.C., Kwok C.L., Ho L.Y., Chan P.T., Yip S.F. Life expectancy, standardized mortality ratios, and causes of death in six rheumatic diseases in Hong Kong, China. Arthritis Rheumatol. 2011;63:1182–1189. doi: 10.1002/art.30277. - DOI - PubMed
    1. Gabriel S.E., Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res. Ther. 2009;11:229. doi: 10.1186/ar2669. - DOI - PMC - PubMed
    1. Yurkovich M., Vostretsova K., Chen W., Aviña-Zubieta J.A. Overall and cause-specific mortality in patients with systemic lupus erythematosus: A meta-analysis of observational studies. Arthritis Care Res. 2014;66:608–616. doi: 10.1002/acr.22173. - DOI - PubMed
    1. Toledano E., Candelas G., Rosales Z., Martínez Prada C., León L., Abásolo L., Loza E., Carmona L., Tobías A., Jover J.A. A meta-analysis of mortality in rheumatic diseases. Reumatol. Clin. 2012;8:334–341. doi: 10.1016/j.reuma.2012.05.006. - DOI - PubMed

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