. 2022 Jul;23(6):585-598.

doi: 10.1111/hiv.13210. Epub 2021 Dec 9.

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Amanda Mocroft^{1

2}, Jose M Miro³, Gilles Wandeler⁴, Josep M Llibre⁵, Anders Boyd^{6

7}, Kathrin van Bremen⁸, Marek Beniowski⁹, Julia Mikhalik¹⁰, Matthias Cavassini¹¹, Fernando Maltez¹², Claudine Duvivier^{13

14

15

16}, Caterina Uberti Foppa¹⁷, Brygida Knysz¹⁸, Elzbieta Bakowska¹⁹, Elena Kuzovatova²⁰, Pere Domingo²¹, Alexandra Zagalo²², Jean-Paul Viard²³, Olaf Degen²⁴, Ana Milinkovic²⁵, Thomas Benfield²⁶, Lars Peters¹; EuroSIDA study group

Collaborators, Affiliations

Collaborators

EuroSIDA study group:
A Harxhi, M Losso, M Kundro, B Schmied, R Zangerle, I Karpov, A Vassilenko, V M Mitsura, D Paduto, N Clumeck, S De Wit, M Delforge, E Florence, L Vandekerckhove, V Hadziosmanovic, J Begovac, L Machala, D Sedlacek, G Kronborg, J Gerstoft, T Katzenstein, C Pedersen, I S Johansen, L Ostergaard, L Wiese, N F Moller, L N Nielsen, K Zilmer, J Smidt, I Aho, K Lacombe, C Pradier, E Fontas, J Rockstroh, G Behrens, C Hoffmann, H J Stellbrink, C Stefan, J Bogner, G Fätkenheuer, N Chkhartishvili, H Sambatakou, G Adamis, N Paissios, J Szlávik, M Gottfredsson, E Devitt, L Tau, D Turner, M Burke, E Shahar, L M Wattad, H Elinav, M Haouzi, D Elbirt, A D'Arminio Monforte, R Esposito, I Mazeu, C Mussini, F Mazzotta, A Gabbuti, A Lazzarin, A Castagna, N Gianotti, M Galli, A Ridolfo, V Uzdaviniene, R Matulionyte, T Staub, R Hemmer, S Dragas, M Stevanovic, M Vd Valk, J Trajanovska, D H Reikvam, A Maeland, J Bruun, B Szetela, M Inglot, R Flisiak, A Grzeszczuk, M Parczewski, K Maciejewska, B Aksak-Was, E Mularska, E Jablonowska, J Kamerys, K Wojcik, I Mozer-Lisewska, B Rozplochowski, K Mansinho, R Radoi, C Oprea, D Gusev, T Trofimova, I Khromova, E Borodulina, J Ranin, J Tomazic, J M Miró, M Laguno, E Martinez, F Garcia, J L Blanco, M Martinez-Rebollar, J Mallolas, P Callau, J Rojas, A Inciarta, S Moreno, S Del Campo, B Clotet, A Jou, R Paredes, J Puig, J R Santos, M Gutierrez, G Mateo, M A Sambeat, J M Laporte, V Svedhem, A Thalme, A Sönnerborg, J Brännström, L Flamholc, K Kusejko, D Braun, A Calmy, H Furrer, M Battegay, P Schmid, A Kuznetsova, M Sluzhynska, A M Johnson, E Simons, S Edwards, A Phillips, M A Johnson, C Orkin, A Winston, A Clarke, C Leen, I Karpov, M Losso, J Lundgren, J Rockstroh, I Aho, L D Rasmussen, V Svedhem, C Pradier, N Chkhartishvili, R Matulionyte, C Oprea, J D Kowalska, J Begovac, J M Miró, G Guaraldi, R Paredes, R Paredes, J F Larsen, A Bojesen, B Neesgaard, N Jaschinski, O Fursa, M Sather, D Raben, E V Hansen, D Kristensen, A H Fischer, S K Jensen, T W Elsing, A Phillips, J Reekie, A Cozzi-Lepri, S Amele, A Pelchen-Matthews, A Roen, E S Tusch, W Bannister

Affiliations

¹ CHIP, Rigshospitalet, Copenhagen, Denmark.
² Centre for Clinical Research Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
³ Hospital Clinic-IDIBAPS University of Barcelona, Barcelona, Spain.
⁴ Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
⁵ Infectious Diseases Unit & Fight AIDS Foundation, Hospital Germans Trias i Pujol, Badalona, Spain.
⁶ Stichting HIV Monitoring (SHM), Amsterdam, the Netherlands.
⁷ Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands.
⁸ Department of Medicine, University Hospital Bonn, Bonn, Germany.
⁹ Diagnostics and Therapy for AIDS, Specialistic Hospital, Chorzów, Poland.
¹⁰ Crimean Republican AIDS Centre, Simferopol, Ukraine.
¹¹ Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
¹² Curry Cabral Hospital, Lisbon, Portugal.
¹³ AP-HP-Necker Hospital, Infectious Diseases Department, Necker-Pasteur Infectiology Center, Paris, France.
¹⁴ University of Paris, INSERM U1016, Paris, France.
¹⁵ HU Imagine, Paris, France.
¹⁶ Institut Pasteur, Institut Pasteur Medical Center, Paris, France.
¹⁷ Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
¹⁸ Wroclaw Medical University, Wroclaw, Poland.
¹⁹ Hospital for Infectious Diseases in Warsaw, Warsaw, Poland.
²⁰ Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia.
²¹ Department of Infectious Diseases, Hospital of the Holy Cross and Saint Paul, Barcelona, Spain.
²² Department of Infectious Diseases, Santa Maria University Hospital, Lisbon, Portugal.
²³ Diagnostic and Therapeutic Center, Hôtel-Dieu, AP-HP, Paris, France.
²⁴ University Clinic Hamburg Eppendorf, Hamburg, Germany.
²⁵ Chelsea and Westminster Hospital, London, UK.
²⁶ Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.

PMID: 34889022
DOI: 10.1111/hiv.13210

Free article

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Amanda Mocroft et al. HIV Med. 2022 Jul.

Free article

. 2022 Jul;23(6):585-598.

doi: 10.1111/hiv.13210. Epub 2021 Dec 9.

Authors

Collaborators

EuroSIDA study group:
A Harxhi, M Losso, M Kundro, B Schmied, R Zangerle, I Karpov, A Vassilenko, V M Mitsura, D Paduto, N Clumeck, S De Wit, M Delforge, E Florence, L Vandekerckhove, V Hadziosmanovic, J Begovac, L Machala, D Sedlacek, G Kronborg, J Gerstoft, T Katzenstein, C Pedersen, I S Johansen, L Ostergaard, L Wiese, N F Moller, L N Nielsen, K Zilmer, J Smidt, I Aho, K Lacombe, C Pradier, E Fontas, J Rockstroh, G Behrens, C Hoffmann, H J Stellbrink, C Stefan, J Bogner, G Fätkenheuer, N Chkhartishvili, H Sambatakou, G Adamis, N Paissios, J Szlávik, M Gottfredsson, E Devitt, L Tau, D Turner, M Burke, E Shahar, L M Wattad, H Elinav, M Haouzi, D Elbirt, A D'Arminio Monforte, R Esposito, I Mazeu, C Mussini, F Mazzotta, A Gabbuti, A Lazzarin, A Castagna, N Gianotti, M Galli, A Ridolfo, V Uzdaviniene, R Matulionyte, T Staub, R Hemmer, S Dragas, M Stevanovic, M Vd Valk, J Trajanovska, D H Reikvam, A Maeland, J Bruun, B Szetela, M Inglot, R Flisiak, A Grzeszczuk, M Parczewski, K Maciejewska, B Aksak-Was, E Mularska, E Jablonowska, J Kamerys, K Wojcik, I Mozer-Lisewska, B Rozplochowski, K Mansinho, R Radoi, C Oprea, D Gusev, T Trofimova, I Khromova, E Borodulina, J Ranin, J Tomazic, J M Miró, M Laguno, E Martinez, F Garcia, J L Blanco, M Martinez-Rebollar, J Mallolas, P Callau, J Rojas, A Inciarta, S Moreno, S Del Campo, B Clotet, A Jou, R Paredes, J Puig, J R Santos, M Gutierrez, G Mateo, M A Sambeat, J M Laporte, V Svedhem, A Thalme, A Sönnerborg, J Brännström, L Flamholc, K Kusejko, D Braun, A Calmy, H Furrer, M Battegay, P Schmid, A Kuznetsova, M Sluzhynska, A M Johnson, E Simons, S Edwards, A Phillips, M A Johnson, C Orkin, A Winston, A Clarke, C Leen, I Karpov, M Losso, J Lundgren, J Rockstroh, I Aho, L D Rasmussen, V Svedhem, C Pradier, N Chkhartishvili, R Matulionyte, C Oprea, J D Kowalska, J Begovac, J M Miró, G Guaraldi, R Paredes, R Paredes, J F Larsen, A Bojesen, B Neesgaard, N Jaschinski, O Fursa, M Sather, D Raben, E V Hansen, D Kristensen, A H Fischer, S K Jensen, T W Elsing, A Phillips, J Reekie, A Cozzi-Lepri, S Amele, A Pelchen-Matthews, A Roen, E S Tusch, W Bannister

Affiliations

¹ CHIP, Rigshospitalet, Copenhagen, Denmark.
² Centre for Clinical Research Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, University College London, London, UK.
³ Hospital Clinic-IDIBAPS University of Barcelona, Barcelona, Spain.
⁴ Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
⁵ Infectious Diseases Unit & Fight AIDS Foundation, Hospital Germans Trias i Pujol, Badalona, Spain.
⁶ Stichting HIV Monitoring (SHM), Amsterdam, the Netherlands.
⁷ Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands.
⁸ Department of Medicine, University Hospital Bonn, Bonn, Germany.
⁹ Diagnostics and Therapy for AIDS, Specialistic Hospital, Chorzów, Poland.
¹⁰ Crimean Republican AIDS Centre, Simferopol, Ukraine.
¹¹ Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
¹² Curry Cabral Hospital, Lisbon, Portugal.
¹³ AP-HP-Necker Hospital, Infectious Diseases Department, Necker-Pasteur Infectiology Center, Paris, France.
¹⁴ University of Paris, INSERM U1016, Paris, France.
¹⁵ HU Imagine, Paris, France.
¹⁶ Institut Pasteur, Institut Pasteur Medical Center, Paris, France.
¹⁷ Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
¹⁸ Wroclaw Medical University, Wroclaw, Poland.
¹⁹ Hospital for Infectious Diseases in Warsaw, Warsaw, Poland.
²⁰ Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia.
²¹ Department of Infectious Diseases, Hospital of the Holy Cross and Saint Paul, Barcelona, Spain.
²² Department of Infectious Diseases, Santa Maria University Hospital, Lisbon, Portugal.
²³ Diagnostic and Therapeutic Center, Hôtel-Dieu, AP-HP, Paris, France.
²⁴ University Clinic Hamburg Eppendorf, Hamburg, Germany.
²⁵ Chelsea and Westminster Hospital, London, UK.
²⁶ Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.

PMID: 34889022
DOI: 10.1111/hiv.13210

Abstract

Objectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH).

Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit.

Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94-8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47-12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00-1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00-1.89) and NHL (aIRR 2.57; 95% CI 1.16-5.68). There was no significant association between HBV and lung or anal cancer.

Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.

Keywords: HBV DNA; hepatitis B; nonliver cancer.

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References

REFERENCES

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1. Platt L , French CE , McGowan CR , et al. Prevalence and burden of HBV co-infection among people living with HIV: a global systematic review and meta-analysis. J Viral Hepat. 2020;27(3):294-315.
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The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Collaborators

Affiliations

The association between hepatitis B virus infection and nonliver malignancies in persons living with HIV: results from the EuroSIDA study

Authors

Collaborators

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical