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Review
. 2021 Dec 10;100(49):e27992.
doi: 10.1097/MD.0000000000027992.

Multiseptate gallbladder: A case report and literature review

Yu-Min Hsieh  1 , Yuli Lily Hsieh  2   3 , Nien-Lu Wang  4 , Pao-Shu Wu  5   6 , Shu-Chao Weng  1
Affiliations
Review

Multiseptate gallbladder: A case report and literature review

Yu-Min Hsieh et al. Medicine (Baltimore). .

Abstract

Rationale: Multiseptate gallbladder (MSG) is a rare congenital gallbladder anomaly. Between 1963 and June 2021, only 56 cases were reported. There is currently no treatment guideline for pediatric or adult cases of MSG.

Patient concerns: A 14-year-old woman visited our out-patient clinic in September 2020 for epigastric pain that last for 6 months. Honeycomb appearance of the gallbladder was noted under ultrasonography.

Diagnosis: The patient was diagnosed with MSG. The diagnosis was confirmed through computed tomography and magnetic resonance cholangiopancreatography.

Interventions: Cholecystectomy was performed.

Outcomes: Epigastric pain showed limited improvement after the surgery. Since she was diagnosed with gastritis at the same time, a proton-pump inhibitor was prescribed. Epigastric pain was eventually resolved.

Lessons: MSG cases can undergo cholecystectomy and show good recovery without complications. However, concomitant treatment may be required to resolve in the presence of other symptoms such as epigastric pain.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Abdominal echo: multiple thin septa in gallbladder without gallstone.
Figure 2
Figure 2
(A) Macroscopically, a grape-like appearance of the gallbladder can be visualized during the laparoscopic procedure. (B) The specimen consisted of a gallbladder measuring 3.5 × 2 × 1.5 cm in size.
Figure 3
Figure 3
Pathology: (A) The serosa was smooth. On section, the wall was 0.5 cm in thickness. The mucosa appeared trabeculated, showing a picture compatible with the multiseptate gallbladder (H&E stain, 10×). (B) Examination under the oil immersion objective revealed muscle layer. Arrow: smooth muscle (H&E stain, 100×).
See this image and copyright information in PMC

References

    1. Simon M, Tandon BN. Multiseptate gallbladder. A case report. Radiology 1963;80:84–6. - PubMed
    1. Haslam RH, Gayler BW, Ebert PA. Multiseptate gallbladder. A cause of recurrent abdominal pain in childhood. Am J Dis Child 1966;112:600–3. - PubMed
    1. Wanaguru D, Jiwane A, Day AS, Adams S. Multiseptate gallbladder in an asymptomatic child. Case Rep Gastrointest Med 2011;2011:470658. - PMC - PubMed
    1. Singh AD, Simons-Linares CR, Chahal P. A dilated common bile duct with “atypical” gallbladder. Gastroenterology 2020;159:e6–7. - PubMed
    1. Esper E, Kaufman DB, Crary GS, Snover DC, Leonard AS. Septate gallbladder with cholelithiasis: a cause of chronic abdominal pain in a 6-year-old child. J Pediatr Surg 1992;27:1560–2. - PubMed