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. 2022 Jan 3;19(1):354-357.
doi: 10.1021/acs.molpharmaceut.1c00780. Epub 2021 Dec 10.

Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death

Darya E Votkina  1 , Evgenii V Plotnikov  1 , Pavel V Petunin  1 , Elizaveta S Berdinskaya  1 , Maria S Tretyakova  1 , Gérard Audran  2 , Sylvain R A Marque  2 , Pavel S Postnikov  1   3
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Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death

Darya E Votkina et al. Mol Pharm. .

Abstract

Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF-7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.

Keywords: alkylated verdazyls; cancer cell death; photolysis.

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