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. 2021 Dec 2;17(12):4964-4970.
doi: 10.1080/21645515.2021.1991183. Epub 2021 Dec 10.

Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study

Heping Zhao  1 , Hui Wang  2 , Hui Li  3 , Weiran Zheng  1 , Tanwei Yuan  1 , Anping Feng  1 , Dan Luo  1 , Yuqing Hu  1 , Yinghui Sun  1 , Yi-Fan Lin  1 , Yiguo Zhou  1 , Ganfeng Luo  1 , Qiaoli Peng  2 , Jianzhou Yang  4 , Junjie Xu  5 , Huachun Zou  1   6   7
Affiliations

Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study

Heping Zhao et al. Hum Vaccin Immunother. .

Abstract

Objectives: The coronavirus disease-2019 (COVID-19) pandemic continues to ravage the world. People living with HIV (PLHIV) are one of the most vulnerable groups. This study aims to identify the factors associated with the uptake and adverse reactions of COVID-19 vaccination.

Methods: We recruited PLHIV in China by convenience sampling between 7 and 23 February 2021. Participants were asked to complete an online questionnaire. Chi-squared test and multivariable logistic regression were used to assess factors associated with vaccine uptake.

Results: A total of 527 vaccinated and 1091 unvaccinated PLHIV were recruited. Individuals who had a higher education, engaged in occupations with a higher risk of COVID-19 infection, received influenza or pneumonia vaccine in the past 3 years (5.40, 3.36-8.77), believed in the effectiveness of vaccines (3.01, 2.20-4.12), and received media information regarding COVID-19 vaccine (2.23, 1.61-3.11), were more likely to be vaccinated. Concerning about adverse reactions (0.31, 0.22-0.44), negative impact on the progression of HIV/AIDS (0.36, 0.26-0.50) or antiretroviral therapy (ART) (0.61, 0.44-0.85), disclosure of HIV infection status (0.69, 0.49-0.96), comorbidities (0.33, 0.22-0.47), being unmarried (0.43, 0.28-0.66) and older age were negatively associated with vaccination. Of the 527 vaccinated PLHIV, 155 (29.4%) PLHIV reported adverse reactions, with pain at the injection site being the most common (18.2%).

Conclusions: PLHIV, who are concerned about adverse reactions, negative impact on ART outcome and disclosure of HIV infection status, were less likely to adopt COVID-19 vaccination. To increase vaccination coverage among PLHIV, health-care professionals should emphasize the benefits and necessity of vaccination and provide consultancy regarding adverse reactions.

Keywords: COVID-19 vaccination; PLHIV; adverse reactions; vaccine uptake.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Adverse reactions among PLHIV after vaccination. The X-axis is the proportion of adverse reactions. The Y-axis is the specific adverse reactions. PLHIV, people living with HIV. Color shaded regions indicate whether participants have adverse reactions (dark blue = yes, light blue = no).
See this image and copyright information in PMC

References

    1. Nicola M, Alsafi Z, Sohrabi C, Kerwan A, Al-Jabir A, Iosifidis C, Agha M, Agha R.. The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int J Surg. 2020;78:185–93. doi:10.1016/j.ijsu.2020.04.018. - DOI - PMC - PubMed
    1. Ahmad T, Haroon BM, Hui J.. Coronavirus disease 2019 (COVID-19) pandemic and economic impact. Pak J Med Sci. 2020;36:S73–8. doi:10.12669/pjms.36.COVID19-S4.2638. - DOI - PMC - PubMed
    1. Ramgobin D, Benson J, Kalayanamitra R, Shahid Z, Cai A, McClafferty B, Groff A, Patel R, Vunnam R, Golamari R, et al. The economic implications of COVID-19 in the United States. S D Med. 2020;73:218–22. - PubMed
    1. Guessoum SB, Lachal J, Radjack R, Carretier E, Minassian S, Benoit L, Moro MR. Adolescent psychiatric disorders during the COVID-19 pandemic and lockdown. Psychiatry Res. 2020;291:113264. doi:10.1016/j.psychres.2020.113264. - DOI - PMC - PubMed
    1. de Figueiredo CS, Sandre PC, Portugal L, Mázala-de-Oliveira T, da Silva Chagas L, Raony Í, Ferreira ES, Giestal-de-Araujo E, dos Santos AA, Bomfim POS. COVID-19 pandemic impact on children and adolescents’ mental health: biological, environmental, and social factors. Prog Neuropsychopharmacol Biol Psychiatry. 2021;106:110171. doi:10.1016/j.pnpbp.2020.110171. - DOI - PMC - PubMed

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