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Comment
. 2021 Dec 9;184(25):6017-6019.
doi: 10.1016/j.cell.2021.11.015.

Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion

Mihe Hong  1 , Yvonne Y Chen  2
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Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion

Mihe Hong et al. Cell. .
Free article

Abstract

Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al. develop an in vitro model of antigen-driven CAR-T cell exhaustion to characterize signatures of dysfunction, including a transition to a natural killer (NK)-like phenotype, and suggest new gene targets to prevent exhaustion.

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  • An NK-like CAR T cell transition in CAR T cell dysfunction.
    Good CR, Aznar MA, Kuramitsu S, Samareh P, Agarwal S, Donahue G, Ishiyama K, Wellhausen N, Rennels AK, Ma Y, Tian L, Guedan S, Alexander KA, Zhang Z, Rommel PC, Singh N, Glastad KM, Richardson MW, Watanabe K, Tanyi JL, O'Hara MH, Ruella M, Lacey SF, Moon EK, Schuster SJ, Albelda SM, Lanier LL, Young RM, Berger SL, June CH. Good CR, et al. Cell. 2021 Dec 9;184(25):6081-6100.e26. doi: 10.1016/j.cell.2021.11.016. Epub 2021 Dec 2. Cell. 2021. PMID: 34861191 Free PMC article.

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