Stem-cell derived pancreatic endoderm cells in the treatment of T1DM

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Comment

Claire Greenhill. Nat Rev Endocrinol. 2022 Feb.

. 2022 Feb;18(2):67.

doi: 10.1038/s41574-021-00620-z.

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Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.
Ramzy A, Thompson DM, Ward-Hartstonge KA, Ivison S, Cook L, Garcia RV, Loyal J, Kim PTW, Warnock GL, Levings MK, Kieffer TJ. Ramzy A, et al. Cell Stem Cell. 2021 Dec 2;28(12):2047-2061.e5. doi: 10.1016/j.stem.2021.10.003. Cell Stem Cell. 2021. PMID: 34861146 Clinical Trial.
Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device.
Shapiro AMJ, Thompson D, Donner TW, Bellin MD, Hsueh W, Pettus J, Wilensky J, Daniels M, Wang RM, Brandon EP, Jaiman MS, Kroon EJ, D'Amour KA, Foyt HL. Shapiro AMJ, et al. Cell Rep Med. 2021 Dec 2;2(12):100466. doi: 10.1016/j.xcrm.2021.100466. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028608 Free PMC article. Clinical Trial.

1. Shapiro, A. M. J. et al. Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device. Cell Rep. Med. https://doi.org/10.1016/j.xcrm.2021.100466 (2021) - DOI - PubMed - PMC
1. Ramzy, A. et al. Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes. Cell Stem Cell 28, 2047–2061.e5 (2021) - DOI

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