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. 2022 Jan;36(1):59-65.
doi: 10.1111/jvim.16312. Epub 2021 Dec 10.

Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea

Elisabeth Skotnitzki  1 , Jan S Suchodolski  2 , Kathrin Busch  1 , Melanie Werner  1 , Yury Zablotski  1 , Bianca D Ballhausen  3 , Felix Neuerer  4 , Stefan Unterer  1
Affiliations

Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea

Elisabeth Skotnitzki et al. J Vet Intern Med. 2022 Jan.

Abstract

Background: Acute enteropathy is a trigger of chronic gastrointestinal (GI) disease in humans.

Objective: To report the prevalence of and explore possible risk factors for signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD).

Animals: One hundred and fifty-one dogs, 80 dogs with a historical diagnosis of AHD, 71 control dogs with no history of AHD.

Methods: In this retrospective longitudinal study, data were collected from dogs with a historical diagnosis of AHD and healthy controls matched by breed, age and sex, aged between 1 year and 15 years of age, for which a follow-up of at least 12 months after enrolment was available. Dog owners responded to a questionnaire to determine the history of signs of chronic GI disease.

Results: There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P = .03; odds ratio = 2.57; confidence interval [CI] 95% 1.12-6.31) over a similar observation time (median 4 years; range, 1-12 years).

Conclusions and clinical importance: Severe intestinal mucosal damage and associated barrier dysfunction might trigger chronic GI disease later in life.

Keywords: AHDS; HGE; IBD; canine; enteropathy; intestinal.

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Conflict of interest statement

Authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Comparison of the Canine Inflammatory Bowel Disease Activity Index (CIBDAI) between dogs with AHD and control dogs. Red lines indicate the median. CIBDAI score was evaluated for the time point with the most severe clinical signs. AHD, acute hemorrhagic diarrhea
FIGURE 2
FIGURE 2
Age at the time of presentation for AHD in dogs with (yes) and without (no) development of signs of chronic GI disease later in life. Red lines indicate the median age. AHD, acute hemorrhagic diarrhea; GI, gastrointestinal
See this image and copyright information in PMC

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