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. 2022 Apr 1;150(7):1174-1183.
doi: 10.1002/ijc.33893. Epub 2021 Dec 22.

Impact of specific high-risk human papillomavirus genotypes on survival in oropharyngeal cancer

Martin Garset-Zamani  1 , Amanda F Carlander  1 , Kathrine K Jakobsen  1 , Jeppe Friborg  2 , Katalin Kiss  3 , Rasmus L Marvig  4 , Caroline Olsen  5 , Finn C Nielsen  4 , Elo Andersen  6 , Christian Grønhøj  1 , Christian von Buchwald  1
Affiliations

Impact of specific high-risk human papillomavirus genotypes on survival in oropharyngeal cancer

Martin Garset-Zamani et al. Int J Cancer. .

Abstract

The increases observed in incidence and survival of oropharyngeal squamous cell carcinoma (OPSCC) have been attributed to human papillomavirus (HPV) infection, but the survival-impact of specific genotypes is poorly understood. We investigated the potential influence of HPV genotypes on survival in HPV-positive (HPV+) OPSCC. All patients with HPV+/p16+ OPSCC and available genotype data within the period 2011 to 2017 in Eastern Denmark were included. Descriptive statistics on clinical and tumor data, as well as overall survival (OS) and recurrence-free survival (RFS) with Cox hazard models and Kaplan-Meier plots were performed. Overall, 769 HPV+/p16+ OPSCC patients were included of which genotype HPV16 accounted for 86% (n = 662). Compared to high-risk non-HPV16 genotypes (HR non-HPV16), HPV16 patients were younger at diagnosis (median years, 60 vs 64), had a higher male to female ratio (3.7:1 vs 2.1:1), and lower performance scores of ≤1 (90%, n = 559, vs 81%, n = 74). Regarding 5-year OS and RFS, no difference was observed between HPV16 and HR non-HPV16 patients. Subgrouping the HR non-HPV16 group into HPV33 (n = 57), HPV35 (n = 26) and "other genotypes" (n = 24) a significantly worse OS in the "other genotypes" group (hazard rate: 2.33, P = .027) was shown. With similar survival results between HPV16 and non-HPV16 genotypes, genotyping in OPSCC is interesting from an epidemiological point of view as well as in vaccination programs, but not a necessary addition in prognostication of HPV+/p16+ OPSCC.

Keywords: HPV genotype; head and neck cancer; human papillomavirus; oropharyngeal cancer; oropharyngeal squamous cell carcinoma.

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References

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