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Review
. 2021 Dec 11;22(1):410.
doi: 10.1186/s12882-021-02615-4.

A case of Podocytic Infolding Glomerulopathy with SLE and literature review

Xi Liu  1 , Jieli Huang  1 , Kun Zhang  1 , Yangyang Niu  1 , Yuting Liu  1 , Chunli Cui  1 , Chen Yu  2
Affiliations
Review

A case of Podocytic Infolding Glomerulopathy with SLE and literature review

Xi Liu et al. BMC Nephrol. .

Abstract

Background: Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus.

Case presentation: A 61-year-old Chinese female was diagnosed with systemic lupus erythematosus with clinical manifestations of proteinuria, pleural effusion, seroperitoneum, anemia, leukopenia, thrombocytopenia, antinuclear antibody positive, and hypocomplementemia. She also had benign ovarian tumor and Epstein-Barr virus infection. Renal biopsy immunofluorescent staining showed IgM and C3 were granularly deposited along the capillary wall instead of typical "full house" features. Electron microscopy showed lots of microspheres structures were seen in the thickened GBM.

Conclusion: We present a case of PIG in a patient with systemic lupus erythematosus. The mechanisms of PIG are unknown, but may be associated with connective tissue disease and podocyte injury.

Keywords: EB virus; Ovarian tumor; Podocytes,Systemic lupus erythematosus; Podocytic infolding glomerulopathy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Renal biopsy findings (A ~ D) A. IgM (400X); B. C3(400X); C.D. Thickened capillary (→) and tubular epithelial cells vacuolar degeneration (→)
Fig. 2
Fig. 2
Microspheres in the thickened GBM (→) and podocytes components trapped in the GBM (→)
See this image and copyright information in PMC

References

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