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Randomized Controlled Trial
. 2021 Dec 11;22(1):900.
doi: 10.1186/s13063-021-05816-2.

Treatment of urinary incontinence in women with chronic obstructive pulmonary disease-a randomised controlled study

Stacey Haukeland-Parker  1 , Bente Frisk  2 , Martijn A Spruit  3   4   5 , Signe Nilssen Stafne  6   7 , Hege Hølmo Johannessen  8   9
Affiliations
Randomized Controlled Trial

Treatment of urinary incontinence in women with chronic obstructive pulmonary disease-a randomised controlled study

Stacey Haukeland-Parker et al. Trials. .

Abstract

Background: Little is known regarding treatment of urinary incontinence (UI) in women with chronic obstructive pulmonary disease (COPD). The aim of the study was to explore the efficacy of pelvic floor muscle training (PFMT) or cough-suppression techniques (CST) on UI in women with COPD.

Methods: A three-armed, two-centred, single-blinded, randomised controlled study was performed. Subjects were randomised to (a) PFMT for 16 weeks, (b) 2-3 educational sessions in CST, or (c) written information only. All participants completed questionnaires about UI, cough symptoms, and health status and underwent clinical examinations to evaluate the strength of the pelvic floor muscles and exercise capacity. Daily physical activity levels were measured using an activity monitor and lung function with spirometry. With a significance level of 5% and an 80% chance of detecting a significant difference between groups of 2.5 points on the ICIQ UI SF score, our sample size calculation showed that a total of 78 women, 26 in each group, was required to complete the study.

Results: During the period 2016 to 2018, 95 women were invited to the study. A total of 42 were recruited, three were excluded and 10 (24%) dropped out during the follow-up period. Mean ICIQ-UI SF total baseline score was 9.6 (range: 1-17) and 7.0 (range: 0-16) at follow-up. Changes in subjective UI as measured with the ICIQ-UI SF questionnaire were seen in the PFMT group and control group, but not in the CST group.

Conclusion: Due to the low number of available participants and recruitment difficulties including practical issues such as travel distance, lack of interest, poor state of health, and high number of comorbidities, our results are inconclusive. However, reduced subjective UI was observed in the PFMT and control groups with a trend towards best effect in the PFMT group. Screening for UI is advisable in all women with COPD to be able to identify and treat these women to reduce symptom burden and improve quality of life. Future studies should focus on barriers to recruitment as well as randomised controlled studies with larger sample sizes.

Trial registration: ClinicalTrials.gov NCT02614105. 25th November 2015.

Keywords: Chronic obstructive pulmonary disease; Cough-suppression therapy; Pelvic floor muscle training; Urinary incontinence.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow chart of the recruitment and inclusion process through each stage of the randomised controlled trial
Fig. 2
Fig. 2
Change in ICIQ-UI SF scores from baseline to post-intervention (n=29)
See this image and copyright information in PMC

References

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