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. 2022 Jan 4;34(1):1-2.
doi: 10.1016/j.cmet.2021.12.002. Epub 2021 Dec 10.

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Martin Zickler  1 , Stephanie Stanelle-Bertram  1 , Sandra Ehret  2 , Fabian Heinrich  3 , Philine Lange  3 , Berfin Schaumburg  1 , Nancy Mounogou Kouassi  1 , Sebastian Beck  1 , Michelle Y Jaeckstein  2 , Oliver Mann  4 , Susanne Krasemann  5 , Maria Schroeder  6 , Dominik Jarczak  6 , Axel Nierhaus  6 , Stefan Kluge  6 , Manuela Peschka  7 , Hartmut Schlüter  7 , Thomas Renné  7 , Klaus Pueschel  3 , Andreas Kloetgen  8 , Ludger Scheja  2 , Benjamin Ondruschka  3 , Joerg Heeren  9 , Guelsah Gabriel  10
Affiliations

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans

Martin Zickler et al. Cell Metab. .

Abstract

Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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