Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Sep 9;159(5):214-223.
doi: 10.1016/j.medcli.2021.10.011. Epub 2021 Nov 15.

Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registry

[Article in English, Spanish]
María Sierra Navas Alcántara  1 , Lorena Montero Rivas  1 , María Esther Guisado Espartero  2 , Manuel Rubio-Rivas  3 , Blanca Ayuso García  4 , Francisco Moreno Martinez  5 , Cristina Ausín García  6 , María Luisa Taboada Martínez  7 , Francisco Arnalich Fernández  8 , Raúl Martínez Murgui  9 , Sonia Molinos Castro  10 , Maria Esther Ramos Muñoz  11 , Mar Fernández-Garcés  12 , Mari Cruz Carreño Hernandez  13 , Gema María García García  14 , Nuria Vázquez Piqueras  15 , Jesica Abadía-Otero  16 , Lourdes Lajara Villar  17 , Cristina Salazar Monteiro  18 , María de Los Reyes Pascual Pérez  19 , Santiago Perez-Martin  20 , Javier Collado-Aliaga  21 , Juan-Miguel Antón-Santos  22 , Carlos Lumbreras-Bermejo  4 ; en nombre del grupo SEMI-COVID-19
Affiliations
Observational Study

Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: results from the SEMI-COVID-19 registry

[Article in English, Spanish]
María Sierra Navas Alcántara et al. Med Clin (Barc). .

Abstract

Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).

Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.

Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.

Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.

Keywords: COVID-19; Hospitalizado; Hospitalized; Mortalidad; Mortality; SARS-CoV-2; Smoking; Tabaquismo.

PubMed Disclaimer

Figures

Figura 1
Figura 1
Diagrama de flujo de la inclusión de los pacientes.
Figura 2
Figura 2
Curvas de Kapplan Meier de mortalidad intrahospitalaria en los pacientes según tabaquismo.
See this image and copyright information in PMC

Comment in

  • Smoking history and clinical outcomes in COVID-19 hospitalized patients.
    Rossato M, Di Vincenzo A. Rossato M, et al. Med Clin (Barc). 2022 Aug 26;159(4):e27. doi: 10.1016/j.medcli.2022.01.025. Epub 2022 Mar 23. Med Clin (Barc). 2022. PMID: 35644628 Free PMC article. No abstract available.
  • Reply.
    Guisado Espartero ME, Navas Alcántara MS, Montero Rivas L. Guisado Espartero ME, et al. Med Clin (Barc). 2022 Aug 26;159(4):e28. doi: 10.1016/j.medcli.2022.03.003. Epub 2022 Apr 25. Med Clin (Barc). 2022. PMID: 35840363 Free PMC article. No abstract available.

References

    1. Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S., et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180:934–943. doi: 10.1001/jamainternmed.2020.0994. - DOI - PMC - PubMed
    1. CDC COVID-19 Response Team Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:382–386. doi: 10.15585/mmwr.mm6913e2. - DOI - PMC - PubMed
    1. Berlin D.A., Gulick R.M., Martinez F.J. Severe Covid-19. N Engl J Med. 2020;383:2451–2460. doi: 10.1056/NEJMcp2009575. - DOI - PubMed
    1. Arcavi L., Benowitz N.L. Cigarette smoking and infection. Arch Intern Med. 2004;164:2206–2216. doi: 10.1001/archinte.164.20.2206. - DOI - PubMed
    1. Strzelak A., Ratajczak A., Adamiec A., Feleszko W. Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. Int J Environ Res Public Health. 2018;15:1033. doi: 10.3390/ijerph15051033. - DOI - PMC - PubMed

Publication types