[DYNAMICS OF INFLAMMATORY MARKERS AFTER SURGERY ON THE DISTAL RECTUM]

Abstract

Objective - to compare the concentrations of inflammatory markers interleukin-6, CRP, and lactoferrin in the serum of patients with benign diseases of the rectum, depending on the volume of surgical intervention and evaluate their changes in different periods after surgery. Been surveyed 92 patients: 54 patients (control group) were operated on for one of the three diseases - chronic hemorrhoids, fistula rectum and chronic anal fissure, 38 patients (main group) operated simultaneously over two or more diseases (combined pathology), where the main were diagnosed with the above diseases. In both groups of patients was determined concentration of interleukin-6, CRP and lactoferrin in serum before surgery, on 3 and 7 days after surgery. There is no communication with the volume of intervention co-operations in the distal rectum with the severity of the systemic inflammatory response. Not identified authentic differences in changes in the concentration of inflammatory markers interleukin-6, C-reactive protein, and lactoferrin in patients operated on for one disease and in patients with combined pathology of the distal colon. The concentration of all investigated markers before operation was higher in both groups of patients diagnosed with anal fissure. The exceptions were the main group of patients with chronic hemorrhoids, in which the concentration of lactoferrin was higher than that of the same group of patients with a diagnosis of the fistula of the rectum and anal fissure. Regardless of the volume of intervention and the type of the marker in patients diagnosed with rectal fistula most pronounced inflammatory reaction was observed on 3-rd day after surgery. Regardless of the volume of operative intervention and nosology on 7-th day after the operation the majority of the studied parameters values approached preoperative, with the exception of both groups consisted of patients diagnosed with anal fissure. Increased of volume of surgical intervention does not lead to a authentic increase in performance of the inflammatory response in patients with combined pathology.