Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov 8;28(6):4504-4520.
doi: 10.3390/curroncol28060382.

Advances in Breast Cancer Management and Extracellular Vesicle Research, a Bibliometric Analysis

Ramon Handerson Gomes Teles  1 , Rafael Sussumu Yano  1 , Nicolas Jones Villarinho  1 , Ana Sayuri Yamagata  1 , Ruy Gastaldoni Jaeger  1 , Patrick Meybohm  2 , Malgorzata Burek  2 , Vanessa Morais Freitas  1
Affiliations
Review

Advances in Breast Cancer Management and Extracellular Vesicle Research, a Bibliometric Analysis

Ramon Handerson Gomes Teles et al. Curr Oncol. .

Abstract

Extracellular vesicles transport variable content and have crucial functions in cell-cell communication. The role of extracellular vesicles in cancer is a current hot topic, and no bibliometric study has ever analyzed research production regarding their role in breast cancer and indicated the trends in the field. In this way, we aimed to investigate the trends in breast cancer management involved with extracellular vesicle research. Articles were retrieved from Scopus, including all the documents published concerning breast cancer and extracellular vesicles. We analyzed authors, journals, citations, affiliations, and keywords, besides other bibliometric analyses, using R Studio version 3.6.2. and VOSviewer version 1.6.0. A total of 1151 articles were retrieved, and as the main result, our analysis revealed trending topics on biomarkers of liquid biopsy, drug delivery, chemotherapy, autophagy, and microRNA. Additionally, research related to extracellular vesicles in breast cancer has been focused on diagnosis, treatment, and mechanisms of action of breast tumor-derived vesicles. Future studies are expected to explore the role of extracellular vesicles on autophagy and microRNA, besides investigating the application of extracellular vesicles from liquid biopsies for biomarkers and drug delivery, enabling the development and validation of therapeutic strategies for specific cancers.

Keywords: bibliometrics; breast cancer; exosomes; extracellular vesicles; metastasis.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1
Figure 1
Number of publications by year.
Figure 2
Figure 2
Historical direct citation network.
Figure 3
Figure 3
Countries that published most on the theme.
Figure 4
Figure 4
Main keyword clusters related to extracellular vesicles and breast cancer.
Figure 5
Figure 5
Average number of citations of the main keywords related to extracellular vesicles and breast cancer.
Figure 6
Figure 6
Average year of appearance of the main keywords related to extracellular vesicles and breast cancer.
See this image and copyright information in PMC

References

    1. Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell. 2011;144:646–674. doi: 10.1016/j.cell.2011.02.013. - DOI - PubMed
    1. Forouzanfar M.H., Afshin A., Alexander L.T., Biryukov S., Brauer M., Cercy K., Charlson F.J., Cohen A.J., Dandona L., Estep K., et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1659–1724. doi: 10.1016/S0140-6736(16)31679-8. - DOI - PMC - PubMed
    1. Harbeck N., Gnant M. Breast cancer. Lancet. 2017;389:1134–1150. doi: 10.1016/S0140-6736(16)31891-8. - DOI - PubMed
    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Guan X. Cancer metastases: Challenges and opportunities. Acta Pharm. Sin. B. 2015;5:402–418. doi: 10.1016/j.apsb.2015.07.005. - DOI - PMC - PubMed

Publication types