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. 2021 Nov 10:12:631454.
doi: 10.3389/fneur.2021.631454. eCollection 2021.

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Wenyuan Ma  1 , Changmeng Cui  2 , Song Feng  2 , Genhua Li  2 , Guangkui Han  2 , Jilan Liu  2 , Xianyun Qin  2 , Yawei Hu  2 , Mengjie Wang  1 , Lu Zhang  1 , Feng Jin  2
Affiliations

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Wenyuan Ma et al. Front Neurol. .

Abstract

Inflammation has been proven to be one of the key factors in the pathogenesis of moyamoya disease (MMD). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are cheap and reliable biomarkers of inflammation. Nevertheless, evidence regarding the relationship among PLR and NLR in patients with MMD is limited. The focus of this subject was to explore the relationship between PLR and NLR in patients with newly diagnosed MMD. Patients and methods: A cross-sectional study was performed including 261 patients with diagnosed MMD for the first time who were enrolled from our hospital, from 24 March 2013 to 24 December 2018. The clinical characteristics were collected for each patient. Univariate analysis, smooth curve fitting and multivariate piecewise linear regression were showed. Results: The mean levels or median values (interquartile range) of PLR and NLR were 146.979 ± 51.203 and 2.241 (1.589-2.984), respectively. A significant positive correlation between PLR and NLR levels (P < 0.001) was showed by the univariate analysis. Furthermore, a non-linear relationship was detected between PLR and NLR by smooth curve fitting after adjusting for potential confounders. A multivariate piecewise linear regression model revealed a significant positive correlation between PLR and NLR when the PLR level was lower than 219.82 (β 0.012, 95% CI 0.005, 0.019; P = 0.001). PLR was also significantly positively associated with NLR when PLR concentrations were >219.82 (β 0.098, 95% CI 0.069, 0.128; P < 0.001). Conclusion: There seemed to be a positive association between PLR and NLR in patients with MMD. This may help to further explain the role of inflammation in the occurrence and progress of MMD.

Keywords: association; inflammation; moyamoya disease; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Association between PLR and NLR in MMD patients. The solid red line stands for the smooth curve fit between the variables. Blue bands stand for the 95% confidence interval of the fit. The pattern was adjusted for sex, age, BMI, smoking status, and alcohol consumption.
Figure 2
Figure 2
Association between PLR and NLR in MMD patients with intracranial ischemia. The solid red line stands for the smooth curve fit between the variables. Blue bands stand for the 95% confidence interval of the fit. The pattern was adjusted for sex, age, BMI, smoking status, and alcohol consumption.
Figure 3
Figure 3
Association between PLR and NLR in MMD patients with intracranial hemorrhage. The solid red line stands for the smooth curve fit between the variables. Blue bands stand for the 95% confidence interval of the fit. The pattern was adjusted for sex, age, BMI, smoking status, and alcohol consumption.
See this image and copyright information in PMC

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