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. 2021 Dec 1:2021:6538079.
doi: 10.1155/2021/6538079. eCollection 2021.

C-Reactive Protein Level Predicts Cardiovascular Risk in Chinese Young Female Population

Ruifang Liu  1 , Fangxing Xu  1 , Qian Ma  1 , Yujie Zhou  1 , Tongku Liu  2
Affiliations

C-Reactive Protein Level Predicts Cardiovascular Risk in Chinese Young Female Population

Ruifang Liu et al. Oxid Med Cell Longev. .

Abstract

Background: C-reactive protein (CRP) is one of the most common oxidative indexes affected by many diseases. In recent years, there have been many studies on CRP, but the relationship between CRP levels and the cardiovascular risk in the Chinese young female population is still unclear. The purpose of this work is to explore the predictive value of CRP for the cardiovascular risk in the Chinese young female population.

Methods: The study is conducted by 1 : 1 case-control to retrospectively analyze 420 young women with acute coronary syndrome (ACS group) who underwent percutaneous coronary intervention (PCI) and 420 young women (control group) who underwent coronary angiography (CAG) to exclude coronary heart disease from January 2007 to December 2016. All patients are divided into three subgroups according to CRP values: subgroup 1: CRP < 1.0 mg/L (n = 402); subgroup 2: 1.0 mg/L ≤ CRP ≤ 3.0 mg/L (n = 303); subgroup 3: CRP > 3.0 mg/L (n = 135). The levels of CRP were observed in the two groups and three subgroups.

Results: A total of 840 patients were analyzed. The mean duration of follow-up was 66.37 ± 30.06 months. The results showed that the level of CRP in the ACS group was significantly higher than that in the control group (1.30 ± 1.70 vs. 3.33 ± 5.92, respectively, p < 0.001), and patients with higher CRP levels were associated with a significantly increased rate of major adverse cardiovascular events (MACE) (7.0% vs. 8.9% vs. 19.30%, respectively, p < 0.05). After adjustment for baseline covariates, CRP level was still an independent predictor for the incidence of MACE, either as a continuous variable or as a categorical variable. There was a significantly higher rate of all-cause mortality and myocardial infarction in patients with higher CRP values during follow-up.

Conclusions: The research results show that high CRP is associated with increased risk of ACS in the Chinese young female population. Risk stratification with CRP as an adjunct to predict clinical risk factors might be useful in the Chinese young female population.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Curve of event-free survival function in three subgroups.
See this image and copyright information in PMC

References

    1. He J., Gu D., Wu X., et al. Major causes of death among men and women in China. The New England Journal of Medicine . 2005;353(11):1124–1134. doi: 10.1056/NEJMsa050467. - DOI - PubMed
    1. Xiao J. J., Chen Y. H. Prevalence of cardiovascular diseases in China. Frontiers of Medicine in China . 2010;4(1):16–20. doi: 10.1007/s11684-010-0007-8. - DOI
    1. Zhao D., Liu J., Wang M., Zhang X., Zhou M. Epidemiology of cardiovascular disease in China: current features and implications. Nature Reviews. Cardiology . 2019;16(4):203–212. doi: 10.1038/s41569-018-0119-4. - DOI - PubMed
    1. Khandelwal A., Bakir M., Bezaire M., et al. Managing ischemic heart disease in women: role of a women's heart center. Current Atherosclerosis Reports . 2021;23(10):p. 56. doi: 10.1007/s11883-021-00956-x. - DOI - PMC - PubMed
    1. Wada H., Miyauchi K., Daida H. Gender differences in the clinical features and outcomes of patients with coronary artery disease. Expert Review of Cardiovascular Therapy . 2019;17(2):127–133. doi: 10.1080/14779072.2019.1561277. - DOI - PubMed

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