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Review
. 2021 Nov 26:9:782237.
doi: 10.3389/fbioe.2021.782237. eCollection 2021.

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

Xingyu Chen  1 , Yu Xie  1 , Zhiqiang Liu  1 , Yunfeng Lin  1   2
Affiliations
Review

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

Xingyu Chen et al. Front Bioeng Biotechnol. .

Abstract

Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.

Keywords: DNA nanomaterials; neurological disorders; tFNA; tetrahedral DNA nanomaterials; tetrahedral framework nucleic acid.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
General characteristics of tFNA. (A) Synthesis of tFNA. (B) The successfully synthesis of tFNA confirmed by 8% PAGE. (C) The molecular weight of ssDNA and tFNA detected by high performance capillary electrophoresis. (D) The size of tFNA. (E) The size and distribution of tFNA analyzed by transmission electron microscope (red triangle). Scale bars are 25 nm. (F) The Zeta potential of tFNA. This article was published in Applied Materials Today, vol.24, Yuting Yang, The remyelination effect of DNA framework nucleic acids on demyelinating diseases, Page No.1-3, Copyright Elsevier.
FIGURE 2
FIGURE 2
Synthesis and programmability of tFNA-based nanomaterials. (A) Synthesis of tFNA with four strands. (B) Simply adding functional groups such as aptamer, cell-penetrating peptides, et al. to tFNA; (C) TFNA-based mixture.
FIGURE 3
FIGURE 3
The possible mechanisms of tFNA-based nanomaterials used in NDs.
FIGURE 4
FIGURE 4
Application of tFNA-based nanomaterials in neurological disorders.
See this image and copyright information in PMC

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