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Review
. 2021 Nov 25:8:662952.
doi: 10.3389/fnut.2021.662952. eCollection 2021.

Low Carbohydrate Diets in Cancer Therapeutics: Current Evidence

Christopher Haskins  1 , Justin Cohen  1 , Rupesh Kotecha  2   3 , Adeel Kaiser  1   2   3
Affiliations
Review

Low Carbohydrate Diets in Cancer Therapeutics: Current Evidence

Christopher Haskins et al. Front Nutr. .

Abstract

Low carbohydrate diets have a promising mechanistic rationale in the treatment of cancer with favorable preclinical data. The strongest data suggest synergistic effects of dietary interventions with traditional cancer therapies. Recent prospective clinical trials suggest that low carbohydrate diets are safely and feasibly added within a busy oncology clinic, with hopeful additive effects in treatment enhancement.

Keywords: cancer; carbohydrate restriction; chemotherapy; immunotherapy; ketogenic diet (KD); metabolism; radiation.

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Conflict of interest statement

RK: Honorarium from Elsevier Inc., Elekta AB, Accuray Inc, Novocure Inc., and Viewray Inc. Research support unrelated to this study from Novocure Inc., Medtronic Inc., Blue Earth Diagnostics, GT Medical Technologies, AstraZeneca, Exelixis, and Viewray Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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