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. 2021 Aug 12;2(4):100151.
doi: 10.1016/j.xinn.2021.100151. eCollection 2021 Nov 28.

Mass spectrometry imaging-based multi-modal technique: Next-generation of biochemical analysis strategy

Chao Zhao  1 , Lei Guo  2 , Jiyang Dong  2 , Zongwei Cai  3
Affiliations

Mass spectrometry imaging-based multi-modal technique: Next-generation of biochemical analysis strategy

Chao Zhao et al. Innovation (Camb). .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Take a typical mouse fetus imaging for example to clarify the characteristics of MSI-based multi-modal technique The molecular variations of mouse fetus are revealed by combing the MSI results with other analytical techniques, such as histological features, image segmentation results, 3D-MSI reconstruction, and in vivo imaging information from MRI and CT. Figures are reprinted from Anal. Chem. Guo, L., et al. 93, 4788–4793, Copyright (2021), with permission from American Chemical Society; NeuroImage. Cleary, J.O., et al. Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping, 54, 769–778, Copyright (2021), with permission from Elsevier; Sci. Bull. Zhao, C., et al. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy, 66, 578–591, Copyright (2021), with permission from Elsevier; Development. Wong, M.D., et al. A novel 3D mouse embryo atlas based on micro-CT, 139, 3248–3256, Copyright (2021), with permission from the Company of Biologists Ltd.; Front. Endocrinol. Danilova, T., et al. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is highly expressed in mouse tissues with metabolic function, 10, 765, Copyright (2021), with permission from Frontiers Research Foundation.
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References

    1. Zhao C., Yong T., Zhang Y., et al. Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A. J. Hazard Mater. 2021;414:125391. - PubMed
    1. Plas R.V., Yang J., Spraggins J., et al. Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping. Nat. Methods. 2015;12:366–372. - PMC - PubMed
    1. Sinha T.K., Khatib-Shahidi S., Yankeelov T.E., et al. Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging. Nat. Methods. 2008;5:57–59. - PMC - PubMed
    1. Wehrl H.F., Schwab J., Hasenbach K., et al. Multimodal elucidation of choline metabolism in a murine glioma model using magnetic resonance spectroscopy and 11C-choline positron emission tomography. Cancer Res. 2013;73:1470–1480. - PubMed

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