Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2021 Dec;19(12):1441-1464.
doi: 10.6004/jnccn.2021.0058.

Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology

Apar Kishor P Ganti  1 , Billy W Loo  2 , Michael Bassetti  3 , Collin Blakely  4 , Anne Chiang  5 , Thomas A D'Amico  6 , Christopher D'Avella  7 , Afshin Dowlati  8 , Robert J Downey  9 , Martin Edelman  10 , Charles Florsheim  11 , Kathryn A Gold  12 , Jonathan W Goldman  13 , John C Grecula  14 , Christine Hann  15 , Wade Iams  16 , Puneeth Iyengar  17 , Karen Kelly  18 , Maya Khalil  19 , Marianna Koczywas  20 , Robert E Merritt  14 , Nisha Mohindra  21 , Julian Molina  22 , Cesar Moran  23 , Saraswati Pokharel  24 , Sonam Puri  25 , Angel Qin  26 , Chad Rusthoven  27 , Jacob Sands  28 , Rafael Santana-Davila  29 , Michael Shafique  30 , Saiama N Waqar  31 , Kristina M Gregory  32 , Miranda Hughes  32
Affiliations
Practice Guideline

Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology

Apar Kishor P Ganti et al. J Natl Compr Canc Netw. 2021 Dec.

Abstract

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer (SCLC) provide recommended management for patients with SCLC, including diagnosis, primary treatment, surveillance for relapse, and subsequent treatment. This selection for the journal focuses on metastatic (known as extensive-stage) SCLC, which is more common than limited-stage SCLC. Systemic therapy alone can palliate symptoms and prolong survival in most patients with extensive-stage disease. Smoking cessation counseling and intervention should be strongly promoted in patients with SCLC and other high-grade neuroendocrine carcinomas. The "Summary of the Guidelines Updates" section in the SCLC algorithm outlines the most recent revisions for the 2022 update, which are described in greater detail in this revised Discussion text.

PubMed Disclaimer

References

    1. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2018, based on November 2020 SEER data submission, posted to the SEER web site, April 2021. Bethesda, MD: National Cancer Institute. Available at: https://seer.cancer.gov/csr/1975_2018/.
    1. Govindan R, Page N, Morgensztern D, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 2006;24:4539–4544. - PubMed
    1. Siegel RL, Miller KD, Fuchs HE, et al. Cancer Statistics, 2021. CA Cancer J Clin 2021;71:7–33. - PubMed
    1. Pesch B, Kendzia B, Gustavsson P, et al. Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer 2012;131:1210–1219. - PMC - PubMed
    1. Jett JR, Schild SE, Kesler KA, et al. Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013;143:e400S–e419S. - PubMed

Publication types

MeSH terms