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. 2021 Dec 21;118(51):e2110986118.
doi: 10.1073/pnas.2110986118.

Historical redlining and cardiovascular health: The Multi-Ethnic Study of Atherosclerosis

Affiliations

Historical redlining and cardiovascular health: The Multi-Ethnic Study of Atherosclerosis

Mahasin S Mujahid et al. Proc Natl Acad Sci U S A. .

Abstract

We investigated historical redlining, a government-sanctioned discriminatory policy, in relation to cardiovascular health (CVH) and whether associations were modified by present-day neighborhood physical and social environments. Data included 4,779 participants (mean age 62 y; SD = 10) from the baseline sample of the Multi-Ethnic Study of Atherosclerosis (MESA; 2000 to 2002). Ideal CVH was a summary measure of ideal levels of seven CVH risk factors based on established criteria (blood pressure, fasting glucose, cholesterol, body mass index, diet, physical activity, and smoking). We assigned MESA participants' neighborhoods to one of four grades (A: best, B: still desirable, C: declining, and D: hazardous) using the 1930s federal Home Owners' Loan Corporation (HOLC) maps, which guided decisions regarding mortgage financing. Two-level hierarchical linear and logistic models, with a random intercept to account for participants nested within neighborhoods (i.e., census tracts) were used to assess associations within racial/ethnic subgroups (non-Hispanic White, non-Hispanic Black, Hispanic, and non-Hispanic Chinese). We found that Black adults who lived in historically redlined areas had a 0.82 (95% CI -1.54, -0.10) lower CVH score compared to those residing in grade A (best) neighborhoods, in a given neighborhood and adjusting for confounders. We also found that as the current neighborhood social environment improved the association between HOLC score and ideal CVH weakened (P < 0.10). There were no associations between HOLC grade and CVH measures or effect modification by current neighborhood conditions for any other racial/ethnic group. Results suggest that historical redlining has an enduring impact on cardiovascular risk among Black adults in the United States.

Keywords: MESA; cardiovascular health; neighborhood; redlining; structural racism.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
HOLC Risk Grade: A = best; B = still desirable; C = declining; D = hazardous Neighborhood physical environment = summary of 3 neighborhood domains (healthy food, physical activity) Neighborhood social environment = summary of 3 neighborhood domains (aesthetic quality, safety and social cohesion.

Comment in

References

    1. Benjamin E. J., et al. , American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart disease and stroke statistics—2017 update: A report from the American Heart Association. Circulation 135, e146–e603 (2017). - PMC - PubMed
    1. Havranek E. P., et al. , American Heart Association Council on Quality of Care and Outcomes Research, Council on Epidemiology and Prevention, Council on Cardiovascular and Stroke Nursing, Council on Lifestyle and Cardiometabolic Health, and Stroke Council, Social determinants of risk and outcomes for cardiovascular disease: A scientific statement from the American Heart Association. Circulation 132, 873–898 (2015). - PubMed
    1. Mensah G. A., Mokdad A. H., Ford E. S., Greenlund K. J., Croft J. B., State of disparities in cardiovascular health in the United States. Circulation 111, 1233–1241 (2005). - PubMed
    1. Lloyd-Jones D. M., et al. , American Heart Association Strategic Planning Task Force and Statistics Committee, Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association’s strategic Impact Goal through 2020 and beyond. Circulation 121, 586–613 (2010). - PubMed
    1. Folsom A. R., et al. , ARIC Study Investigators, Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J. Am. Coll. Cardiol. 57, 1690–1696 (2011). - PMC - PubMed

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