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. 2022 Mar;247(5):377-384.
doi: 10.1177/15353702211063839. Epub 2021 Dec 14.

Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study

Jingyu Wang  1 , Andrew Baker  2 , Manju L Subramanian  3 , Nicole H Siegel  3 , Xuejing Chen  3 , Steven Ness  3 , Ji Yi  1   2
Affiliations

Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study

Jingyu Wang et al. Exp Biol Med (Maywood). 2022 Mar.

Abstract

A dual-channel optical coherence tomography system with wavelengths in the visible and near-infrared light ranges can provide both structural and functional information for retinal microvasculature simultaneously. We applied this integrated system in an ongoing clinical study of patients with various retinal pathologies. Here, we present case study results of patients with diabetic retinopathy, central retinal vein occlusion, and sickle cell retinopathy compared to a healthy subject. For the first time, this comparison validates the system's ability to detect structural anomalies in both en face and B-scan images with simultaneous retinal optical coherence tomography angiography and measurement of sO2 in parafoveal vessels that are around 20-30 µm in diameter. This integrated system represents a powerful instrument with potentially far-reaching clinical implications for the early detection and diagnosis of retinal vascular diseases.

Keywords: Visible light optical coherence tomography; angiography; retinal oximetry.

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Conflict of interest statement

DECLARATION OF CONFLICTING INTERESTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Data processing of dual-channel OCT. (A color version of this figure is available in the online journal.) ILM: internal limiting membrane; RPE: retinal pigment epithelium; ROI: region of interest; STFT: short-time Fourier transform.
Figure 2.
Figure 2.
Healthy subject. (a) and (b) En face images of OCTA and VIS-OCT. (c), (d) and (e) B-scans of NIR-OCT, OCTA, and VIS-OCT from the location of yellow dash line. Scale bar: 200 µm. (A color version of this figure is available in the online journal.)
Figure 3.
Figure 3.
Patient with moderate NPDR without macular edema. (a) and (b) En face images of OCTA and VIS-OCT. (c), (d) and (e) B-scans of NIR-OCT, OCTA, and VIS-OCT from the location of yellow dash line. Scale bar: 200 µm. (A color version of this figure is available in the online journal.)
Figure 4.
Figure 4.
CRVO patient. (a) and (b) En face images of OCTA and VIS-OCT. (c), (d) and (e) B-scan of NIR-OCT, OCTA, and VIS-OCT from the location of yellow dash line. Scale bar: 200 µm. (A color version of this figure is available in the online journal.)
Figure 5.
Figure 5.
SCR patient. (a) and (b) En face images of OCTA and VIS-OCT. (c), (d) and (e) B-scan of NIR-OCT, OCTA, and VIS-OCT from the location of yellow dash line. Scale bar: 200 µm. (A color version of this figure is available in the online journal.)
See this image and copyright information in PMC

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