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. 2022 Jan 1;106(1):e46-e51.
doi: 10.1097/TP.0000000000003996.

Nonhepatic Cancer in the Pediatric Liver Transplant Population: Guidelines From the ILTS-SETH Consensus Conference

Mohamed Rela  1 , Jesus Quintero  2 , Mureo Kasahara  3 , Paolo Muiesan  4 , Francisco Hernández-Oliveros  5 , Rajesh Rajalingam  1 , Sadhana Shankar  6 , Blayne Amir Sayed  7 , Diego di Sabato  8 , Ashwin Rammohan  1 , John Fung  9 , Itxarone Bilbao  10
Affiliations
Free article

Nonhepatic Cancer in the Pediatric Liver Transplant Population: Guidelines From the ILTS-SETH Consensus Conference

Mohamed Rela et al. Transplantation. .
Free article

Abstract

The incidence and geographical distribution of cancers in children are dramatically different from the adult population. Consequent to improvements in postcancer survival, there is a progressive increase in the number of patients requiring liver transplantation (LT) who are in remission from pretransplant malignancy (PTM). Conventionally, however, PTM has been considered a relative contraindication to LT. Furthermore, with improving post-LT survival now extending beyond decades, the cumulative effect of immunosuppression and the increasing risk of de novo cancers need to be acknowledged. A working group was formed to evaluate, discuss, and retrieve all the evidence and provide guidelines with regards to best practices surrounding nonhepatic cancer in the pediatric LT (PLT) population. Further subsections of research included (a) extrahepatic solid tumors, leukemia, lymphoma, and other hematological disturbances before PLT and (b) malignancies following PLT (including posttransplant lymphoproliferative disorders). This guidance provides a collection of evidence-based expert opinions, consensus, and best practices on nonhepatic cancers in PLT.

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Conflict of interest statement

The authors declare no funding or conflicts of interest.

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