Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Nov;60(2):754-60.
doi: 10.1128/JVI.60.2.754-760.1986.

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity

E Terwilliger, J G Sodroski, C A Rosen, W A Haseltine

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity

E Terwilliger et al. J Virol. 1986 Nov.

Abstract

Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.

PubMed Disclaimer

References

    1. Science. 1985 Jan 11;227(4683):177-82 - PubMed
    1. N Engl J Med. 1984 Nov 15;311(20):1286-92 - PubMed
    1. Cell. 1985 Jan;40(1):9-17 - PubMed
    1. Nature. 1985 Jan 24-30;313(6000):277-84 - PubMed
    1. Nature. 1985 Feb 7-13;313(6002):450-8 - PubMed

Publication types

Substances

Associated data

LinkOut - more resources