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. 1986 Aug;25(8):947-9.
doi: 10.1016/0028-3908(86)90027-4.

Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393

M Mashurano, J L Waddington

Stereotyped behaviour in response to the selective D-2 dopamine receptor agonist RU 24213 is enhanced by pretreatment with the selective D-1 agonist SK&F 38393

M Mashurano et al. Neuropharmacology. 1986 Aug.

Abstract

When given alone, 2.5 mg/kg of the selective D-2 agonist RU 24213 was a threshold dose for the induction of weak stereotyped behaviour, while 15 mg/kg of the selective D-1 agonist SK&F 38393 failed to induce stereotypy. Responses to 2.5 mg/kg RU 24213 were dose-dependently potentiated by 3.0-15.0 mg/kg SK&F 38393, and compulsive stereotypy was only evident in animals receiving the combination treatment. Increasing D-1 dopaminergic activity appears to promote the expression of behaviours initiated through D-2 receptor stimulation.

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