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Comment
. 2021 Dec 13;39(12):1576-1577.
doi: 10.1016/j.ccell.2021.11.009.

Improving immunotherapy response through the use of designer bacteria

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Improving immunotherapy response through the use of designer bacteria

Matthew E Griffin et al. Cancer Cell. .
Free article

Abstract

Reprogramming the tumor microenvironment may be a key strategy to broaden the efficacy of current cancer immunotherapies. In a recent Nature paper, Canale et al. use synthetic biology to alter intratumoral arginine levels via engineered bacteria, leading to improved responsiveness to anti-PD-L1 checkpoint blockade in a murine model of cancer.

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Conflict of interest statement

Declaration of interests M.E.G. and H.C.H. have filed a patent application (PCT/US2020/019038) for the commercial use of SagA bacteria to improve checkpoint blockade immunotherapy.

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