The burden of respiratory syncytial virus in children under 5 years of age in Norway

Affiliations

¹ Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway; Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway. Electronic address: l.b.havdal@medisin.uio.no.
² Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway.
³ Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway; Department of Microbiology, Oslo University Hospital, Ullevål, Postboks 4950 Nydalen, 0424 Oslo, Norway.
⁴ Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Ullevål, Postboks, 4950 Nydalen, 0424 Oslo, Norway.
⁵ Department of Paediatrics, Østfold Hospital, Kalnes, Postboks 300, 1714 Grålum, Norway; Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁶ Department of Medical Microbiology, Østfold Hospital, Kalnes, Postboks 300, 1714 Grålum, Norway.
⁷ Department of Paediatrics, St. Olavs University Hospital, Postboks 3250 Torgarden, 7006 Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Norway.
⁸ Department of Medical Microbiology, St. Olavs University Hospital, Postboks 3250 Torgarden, 7006 Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Norway.
⁹ Department of Paediatric and adolescent Medicine, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway.
¹⁰ Department of Medical Microbiology, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway.
¹¹ Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway; Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹² Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway.

PMID: 34906596
DOI: 10.1016/j.jinf.2021.12.008

The burden of respiratory syncytial virus in children under 5 years of age in Norway

Lise Beier Havdal et al. J Infect. 2022 Feb.

. 2022 Feb;84(2):205-215.

doi: 10.1016/j.jinf.2021.12.008. Epub 2021 Dec 11.

Authors

Affiliations

¹ Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway; Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway. Electronic address: l.b.havdal@medisin.uio.no.
² Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway.
³ Norwegian Institute of Public Health, PO BOX 222 Skøyen, 0213, Oslo, Norway; Department of Microbiology, Oslo University Hospital, Ullevål, Postboks 4950 Nydalen, 0424 Oslo, Norway.
⁴ Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Ullevål, Postboks, 4950 Nydalen, 0424 Oslo, Norway.
⁵ Department of Paediatrics, Østfold Hospital, Kalnes, Postboks 300, 1714 Grålum, Norway; Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁶ Department of Medical Microbiology, Østfold Hospital, Kalnes, Postboks 300, 1714 Grålum, Norway.
⁷ Department of Paediatrics, St. Olavs University Hospital, Postboks 3250 Torgarden, 7006 Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Norway.
⁸ Department of Medical Microbiology, St. Olavs University Hospital, Postboks 3250 Torgarden, 7006 Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Norway.
⁹ Department of Paediatric and adolescent Medicine, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway.
¹⁰ Department of Medical Microbiology, Stavanger University Hospital, Postboks 8100, 4068 Stavanger, Norway.
¹¹ Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway; Division of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
¹² Department of Paediatric and Adolescent Medicine, Akershus University Hospital, Postboks 1000, 1478 Lørenskog, Norway.

PMID: 34906596
DOI: 10.1016/j.jinf.2021.12.008

Erratum in

Corrigendum to 'The burden of respiratory syncytial virus in children under 5 years of age in Norway' [Journal of Infection Volume 84, Issue 2 (2022) Pages 205-215].
Havdal LB, Bøås H, Bekkevold T, Kran AB, Rojahn AE, Størdal K, Debes S, Døllner H, Nordbø SA, Barstad B, Haarr E, Fernández LV, Nakstad B, Inchley C, Flem E. Havdal LB, et al. J Infect. 2023 Apr;86(4):420. doi: 10.1016/j.jinf.2022.12.018. Epub 2022 Dec 24. J Infect. 2023. PMID: 36572618 No abstract available.

Abstract

Objectives: To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.

Methods: Active prospective hospital surveillance for RSV in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were enrolled based on respiratory symptoms regardless of fever. Surveillance data were linked to national registry data to estimate the clinical burden of RSV.

Results: Of the children enrolled, 1096 (40%) were infected with RSV. The highest incidence rates were found in children 1 month of age, with a peak incidence of 43 per 1000 during the 2016-2017 season. In comparison, children 24-59 months of age had an infection rate of 1.4 per 1000 during the same winter season. The peak season was during the 2016-2017 winter, with an incidence rate of 6.0 per 1000 children 0-59 months of age. In the study population a total of 168 (15%) of the infected children had pre-existing medical conditions predisposing for more severe disease. High infection rates were found in this population.

Conclusions: Children with comorbidities showed high hospital contact rates, but the majority of children in need of medical attention associated with RSV infection were previously healthy.

Keywords: Children; Disease burden; RSV; Respiratory syncytial virus; Surveillance.

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Conflict of interest statement

Declaration of Competing Interest Elmira Flem is currently employed by Merck Sharp & Dohme Corp., Drammen, Norway, a subsidiary of Merck & Co., Inc., Kenilworth, New Jersey. The work for the current study was conducted by Dr. Flem under the previous affiliation. The author(s) hereby declare that no other conflicts of interest exist.

Comment in

Microorganisms in patients with acute respiratory tract infections in Bamako, Mali.
Xiang Z, Sangaré AK, Wang X, Xiao Y, Kané B, Cissé I, Camara M, Traore B, Dembele A, Wang Y, Ouedraogo J, Timbine LG, Diallo S, Komurian-Pradel F, Doumbo OK, Ren L, Kouriba B, Wang J. Xiang Z, et al. J Infect. 2022 Oct;85(4):e83-e85. doi: 10.1016/j.jinf.2022.07.012. Epub 2022 Jul 22. J Infect. 2022. PMID: 35878685 No abstract available.

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The burden of respiratory syncytial virus in children under 5 years of age in Norway

Affiliations

The burden of respiratory syncytial virus in children under 5 years of age in Norway

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

Comment in

Publication types

MeSH terms