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Review
. 2019 Jun;17(2):91-98.
doi: 10.32725/jab.2019.006. Epub 2019 Apr 15.

MR compatible ergometers for dynamic 31P MRS

Petr Sedivy  1 , Monika Dezortova  1 , Jan Rydlo  1 , Miloslav Drobny  1 , Martin Krssak  2   3 , Ladislav Valkovic  4   5 , Milan Hajek  1
Affiliations
Free article
Review

MR compatible ergometers for dynamic 31P MRS

Petr Sedivy et al. J Appl Biomed. 2019 Jun.
Free article

Abstract

Magnetic Resonance (MR) compatible ergometers are specialized ergometers used inside the MR scanners for the characterization of tissue metabolism changes during physical stress. They are most commonly used for dynamic phosphorous magnetic resonance spectroscopy (31P MRS), but can also be used for lactate production measurements, perfusion studies using arterial spin labelling or muscle oxygenation measurements by blood oxygen dependent contrast sequences. We will primarily discuss the importance of ergometers in the context of dynamic 31P MRS. Dynamic 31P MRS can monitor muscle fatigue and energy reserve during muscle contractions as well as the dynamics of recuperation of skeletal muscle tissue during the following recovery through signal changes of phosphocreatine (PCr), inorganic phosphate and adenosine triphosphate (ATP). Based on the measured data it is possible to calculate intracellular pH, metabolic flux of ATP through creatine-kinase reaction, anaerobic glycolysis and oxidative phosphorylation and other metabolic parameters as mitochondrial capacity. This review primarily focuses on describing various technical designs of MR compatible ergometers for dynamic 31P MRS that must be constructed with respect to the presence of magnetic field. It is also expected that the construction of ergometers will be easy for the handling and well accepted by examined subjects.

Keywords: Dynamic 31P magnetic resonance spectroscopy; Exercise; MR ergometer; Muscle examination.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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