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. 2022 Jan;17(1):11-22.
doi: 10.2217/rme-2021-0019. Epub 2021 Dec 15.

Personalized multitarget biologic injection in the spine: prospective case series of multitarget platelet-rich plasma for low back pain

Edilson S Machado  1   2 , Mary A Ambach  3 , José Mp Caldas  4 , Jason J Wei  5 , Markus Bredemeier  6
Affiliations

Personalized multitarget biologic injection in the spine: prospective case series of multitarget platelet-rich plasma for low back pain

Edilson S Machado et al. Regen Med. 2022 Jan.

Abstract

Aim: To evaluate the use of a multitarget platelet-rich plasma (PRP) injection approach for the treatment of chronic low back pain (LBP). Materials & Methods: Forty-six patients with more than 12 weeks of LBP who failed conservative treatments were injected with PRP into the facet joints, intervertebral discs, epidural space and/or paravertebral muscles. Visual analog pain scale and Roland-Morris Disability Questionnaire scores were measured at baseline and predefined intervals. Results: Mean visual analog pain scale was reduced from 8.48 to 5.17 and mean Roland-Morris Disability Questionnaire from 18.0 to 10.98 at 12 weeks (p < 0.001). These statistically significant improvements were sustained over 52 weeks. No adverse effects were observed. Conclusion: Our PRP approach demonstrated clinically favorable results and may be a promising treatment for chronic LBP.

Keywords: degenerative disc disease; epidural; facet joint pain; low back pain; nonsurgical management; platelet-rich plasma; radiculopathy; regenerative; spine; spondylosis.

Plain language summary

Lay abstract Back pain can be caused by a variety of conditions. Most long-term (chronic) low back pain cases involve one or more parts of the spine causing the pain. This study describes 46 people who received injections of a blood-based substance called platelet-rich plasma into multiple parts of their spine to address chronic low back pain. The patients were followed up at several time points over the course of the following year. The results showed that the patients had improvement in their pain and disability. There was also a reduction in oral pain medication use. No unexpected medical problems were seen with this treatment. This study shows promising results for the treatment of chronic back pain.

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