Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control

Jaclyn W McAlees¹, Theresa Baker², Lauren Houshel¹, Christopher McKnight^{3

4}, Andrew Lindsley^{5

6}, Richard T Strait⁷, Xue Zhang⁸, Angela Cannata^{1

9}, Jocelyn M Biagini^{2

6}, Melinda Butsch Kovacic^{2

6

10}, Ian P Lewkowich^{1

6}

Affiliations

¹ Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
² Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
³ Division of Allergy, Immunology and Rheumatology, University of Cincinnati, Cincinnati, Ohio, USA.
⁴ Medical Service, Cincinnati Veteran's Administration, Cincinnati, Ohio, USA.
⁵ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
⁶ Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
⁷ Department of Emergency Medicine, Department of Pediatrics, Dayton Children's Hospital and Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
⁸ Department of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
⁹ Immunology Graduate Program, University of Cincinnati, Cincinnati, Ohio, USA.
¹⁰ College of Allied Health Sciences, University of Cincinnati, Cincinnati, Ohio, USA.

Jaclyn W McAlees et al. Clin Exp Allergy. 2022 Apr.

. 2022 Apr;52(4):569-573.

doi: 10.1111/cea.14080. Epub 2021 Dec 27.

¹ Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
² Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
³ Division of Allergy, Immunology and Rheumatology, University of Cincinnati, Cincinnati, Ohio, USA.
⁴ Medical Service, Cincinnati Veteran's Administration, Cincinnati, Ohio, USA.
⁵ Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
⁶ Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
⁷ Department of Emergency Medicine, Department of Pediatrics, Dayton Children's Hospital and Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
⁸ Department of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
⁹ Immunology Graduate Program, University of Cincinnati, Cincinnati, Ohio, USA.
¹⁰ College of Allied Health Sciences, University of Cincinnati, Cincinnati, Ohio, USA.

No abstract available

Keywords: IL-17A; asthma; epithelial cells; paediatrics.

Conflict of interest statement

Conflict of Interest:

AL is currently employed by Amgen, in a role unrelated to the submitted work. The other authors report no conflicts of interest.

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