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. 2022 Jan 5:88:153590.
doi: 10.1016/j.tetlet.2021.153590. Epub 2021 Dec 9.

Total synthesis of remdesivir

Kishore Kumar Palli  1   2 , Palash Ghosh  1   2 , Shiva Krishna Avula  1   2 , B Sridhara Shanmukha Rao  1   2 , Amol D Patil  1   2 , Subhash Ghosh  1   2 , Gangarajula Sudhakar  1   2 , Chada Raji Reddy  1   2 , Prathama S Mainkar  1   2 , Srivari Chandrasekhar  1   2
Affiliations

Total synthesis of remdesivir

Kishore Kumar Palli et al. Tetrahedron Lett. .

Abstract

Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield.

Keywords: COVID-19; Nucleoside; Nucleotide; RdRp; Remdesivir.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Srivari Chandrasekhar reports financial support was provided by Science and Engineering Research Board.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Structures of remdesivir and other related antiviral drugs.
Scheme 1
Scheme 1
Gilead route for the synthesis of remdesivir (1, GS-5734).
Scheme 2
Scheme 2
Synthesis of 5-O-TBDPS-2,3-O-diallyl ribonolactone (15).
Scheme 3
Scheme 3
Total synthesis of remdesivir (1, GS-5734).
See this image and copyright information in PMC

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