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Review
. 2021 Jul-Sep;14(3):285-295.
doi: 10.4103/JCAS.JCAS_109_20.

Intralesional Agents in Dermatology: Pros and Cons

Jagdish Sakhiya  1 , Dhruv Sakhiya  2 , Jitesh Kaklotar  1 , Bansi Hirapara  1 , Madhav Purohit  1 , Krishna Bhalala  1 , Feral Daruwala  1 , Nimish Dudhatra  1
Affiliations
Review

Intralesional Agents in Dermatology: Pros and Cons

Jagdish Sakhiya et al. J Cutan Aesthet Surg. 2021 Jul-Sep.

Abstract

Since introduced in 1961, intralesional (IL) agent has become an essential part of the dermatological practice. The term IL referred to the direct delivery of agent percutaneously into skin lesions. This therapeutic approach is relatively safe, easy to perform and applicable for a broad range of dermatological conditions. On the other hand, immediate side effects, including pain during administration, bleeding, high risk of infection and allergic reaction, and subsequent side effects involving skin changes such as atrophy, telangiectasia, pigmentary changes, and striae are usually associated with this modality. This review paper highlights the pros and cons of IL agents in modern dermatology practice.

Keywords: 5-Fluorouracil; Because intralesional agents are relatively safe, easy to implement, and effective in a broad spectrum of dermatological indication with excellent success rate and minimum systemic side effects, the trends in its use have been emerging nowadays. Pros over the cons make it a preferred choice in the dermatology field.; bleomycin; botulinum toxin-A and hyaluronic acid fillers; corticosteroids; cryotherapy; immunotherapy; intralesional agents; mesotherapy; platelet-rich plasma.

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Conflict of interest statement

There are no conflicts of interest.

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