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. 1986 Summer;3(3):189-96.
doi: 10.1089/cdd.1986.3.189.

Effect of chemical deglycosylation on the in vivo fate of ricin A-chain

D C Blakey, P E Thorpe

Effect of chemical deglycosylation on the in vivo fate of ricin A-chain

D C Blakey et al. Cancer Drug Deliv. 1986 Summer.

Abstract

Chemical deglycosylation of ricin A-chain virtually eliminated its entrapment by the liver and delayed its clearance from the bloodstream of mice. Liver entrapment of native ricin A-chain occurred to approximately equal extents in the parenchymal and non-parenchymal cell fractions of the liver. The chemical deglycosylation procedure reduced uptake of the A-chain by both cell fractions.

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