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Review
. 2021 Nov 26;13(11):1610-1624.
doi: 10.4252/wjsc.v13.i11.1610.

Application of dental stem cells in three-dimensional tissue regeneration

Hui-Yi Hsiao  1 , Chung-Yi Nien  2 , Hsiang-Hsi Hong  3 , Ming-Huei Cheng  1 , Tzung-Hai Yen  1
Affiliations
Review

Application of dental stem cells in three-dimensional tissue regeneration

Hui-Yi Hsiao et al. World J Stem Cells. .

Abstract

Dental stem cells can differentiate into different types of cells. Dental pulp stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, stem cells from apical papilla, and dental follicle progenitor cells are five different types of dental stem cells that have been identified during different stages of tooth development. The availability of dental stem cells from discarded or removed teeth makes them promising candidates for tissue engineering. In recent years, three-dimensional (3D) tissue scaffolds have been used to reconstruct and restore different anatomical defects. With rapid advances in 3D tissue engineering, dental stem cells have been used in the regeneration of 3D engineered tissue. This review presents an overview of different types of dental stem cells used in 3D tissue regeneration, which are currently the most common type of stem cells used to treat human tissue conditions.

Keywords: Dental follicle progenitor cells; Dental pulp stem cells; Dental stem cells; Periodontal ligament stem cells; Stem cells from apical papilla; Stem cells from human exfoliated deciduous teeth; Three-dimensional tissue regeneration.

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Conflict of interest statement

Conflict-of-interest statement: Authors have no conflict of interest for this manuscript.

Figures

Figure 1
Figure 1
Schematic illustration of dental stem cells in three-dimensional tissue regeneration. A: Five different types of dental stem cells are harvested during different tooth developmental stages; B: Dental stem cells are incorporated with various forms of three-dimensional (3D) biomaterials (microspheres, hydrogels, or 3D printed scaffolds) to generate 3D engineered tissue; C: Dental stem cells are induced to differentiate into different types of tissue, such as teeth, neurons, bone, blood vessels and cartilage.
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