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Review
. 2021 Nov 25;10(6):301-311.
doi: 10.5501/wjv.v10.i6.301.

Impact of COVID-19 on liver disease: From the experimental to the clinic perspective

Sheila Gato  1 , Ana Lucena-Valera  2 , Rocío Muñoz-Hernández  1 , José Manuel Sousa  2 , Manuel Romero-Gómez  1 , Javier Ampuero  1
Affiliations
Review

Impact of COVID-19 on liver disease: From the experimental to the clinic perspective

Sheila Gato et al. World J Virol. .

Abstract

Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a predominantly respiratory infection, various degrees of liver function abnormalities have been reported. Pre-existing liver disease in patients with SARS-CoV-2 infection has not been comprehensively evaluated in most studies, but it can critically compromise survival and trigger hepatic decompensation. The collapse of the healthcare services has negatively impacted the diagnosis, monitoring, and treatment of liver diseases in non-COVID-19 patients. In this review, we aim to discuss the impact of COVID-19 on liver disease from the experimental to the clinic perspective.

Keywords: COVID 19; Liver disease; SARS-CoV-2; Transaminases.

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Conflict of interest statement

Conflict-of-interest statement: No conflicts of interest.

Figures

Figure 1
Figure 1
Coronavirus outbreak: World map of confirmed cases (updated March 21st, 2021). COVID-19: Coronavirus disease 2019.
Figure 2
Figure 2
Proposed mechanisms of liver injury related to severe acute respiratory syndrome coronavirus 2 infection. SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

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