Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct 6;8(5):485-492.
doi: 10.14744/nci.2021.04317. eCollection 2021.

Xanthogranulomatus inflammatory lesion mimicker of malignancy: A clinicopathological study from rural India

Mani Krishna  1 , Seema Dayal  1
Affiliations

Xanthogranulomatus inflammatory lesion mimicker of malignancy: A clinicopathological study from rural India

Mani Krishna et al. North Clin Istanb. .

Abstract

Objective: Xanthogranulomatus inflammation is an uncommon variant of chronic inflammation and a well-established pathological entity involving various organs and systems. It may be associated with infection and obstruction, defective lipid transport, immunological disturbances, and often confused as a malignant neoplasm. The confirmative diagnosis is made on histopathology.

Methods: This is a retrospective study conducted from January 2008 to April 2020 on histopathologically diagnosed xanthogranulomatus lesions. All the relevant available data regarding age, sex, and organ involvement were collected from histopathology lab records. The macroscopic and microscopic evaluation of cases was also done. This study was aimed to determine the significance of histopathology in the diagnosis of xanthogranulomatus lesions, revealing pathological changes, and clinicopathological correlation.

Results: In the current study, there were 93 cases of xanthogranulomatus inflammatory lesion. Gall bladder was frequently involved 70 (75.27%), followed by 5 (5.37%) kidney, gastrointestinal Tract 6 (3 [3.23%] cases in colon and 3 [3.23%] in appendix, respectively), and others. The maximum number of cases was in the age group of 31-40 years with 24 (25.80%) cases. The female to male sex ratio was 2.3:1.

Conclusion: Awareness and knowledge of xanthogranulomatus inflammatory lesion is significant to the pathologist and surgeon to prevent extensive surgery. This lesion often mimics as malignancy and confirmatory diagnosis is made on histopathology. Thus, every excised specimen must be examined histopathologically to diagnose and rule out differential.

Keywords: Histopathology; Touton giant cell; lipid-laden macrophages; malignancy; xanthogranulomatus inflammation.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

FIGURE 1
FIGURE 1
(A) H&E (×10) stained section of Xanthogranulomatus lesion gall bladder. (B) H&E (×10) stained section of Xanthogranulomatus lesion kidney.
FIGURE 2
FIGURE 2
H&E (×40) stained section of Xanthogranulomatus lesion testis.
FIGURE 3
FIGURE 3
H&E (×40) stained section of Xanthogranulomatus lesion endometrium.
See this image and copyright information in PMC

References

    1. Goodman ZD, Ishak KG. Xanthogranulomatous cholecystitis. Am J Surg Pathol. 1981;5:653–9. - PubMed
    1. Lee HY, Kuo YT, Tsai SY, Li CC, Wu WJ, Huang CH, et al. Xanthogranulomatous prostatitis:a rare entity resembling prostate adenocarcinoma with magnetic resonance image picture. Clin Imaging. 2012;36:858–60. - PubMed
    1. Kang TW, Lee KH, Piao CZ, Yun KJ, Joo HJ, Park KS, et al. Three cases of xanthogranulomatous epididymitis caused by E. coli. J Infect. 2007;54:e69–73. - PubMed
    1. Nishimura M, Nishihira T, Hirose T, Ishikawa Y, Yamaoka R, Inoue H, et al. Xanthogranulomatous pancreatitis mimicking a malignant cystic tumor of the pancreas:report of a case. Surg Today. 2011;41:1310–3. - PubMed
    1. Koo JS, Jung W. Xanthogranulomatous mastitis:clinicopathology and pathological implications. Pathol Int. 2009;59:234–40. - PubMed

LinkOut - more resources