Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 24:2:100013.
doi: 10.1016/j.crphar.2020.100013. eCollection 2021.

Effect of pharmacological manipulations on Arc function

Dina W Yakout  1 , Nitheyaa Shree  1 , Angela M Mabb  1
Affiliations
Review

Effect of pharmacological manipulations on Arc function

Dina W Yakout et al. Curr Res Pharmacol Drug Discov. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Curr Res Pharmacol Drug Discov. 2021 Jun 24;2:100032. doi: 10.1016/j.crphar.2021.100032. eCollection 2021. Curr Res Pharmacol Drug Discov. 2021. PMID: 34911058 Free PMC article.

Abstract

Activity-regulated cytoskeleton-associated protein (Arc) is a brain-enriched immediate early gene that regulates important mechanisms implicated in learning and memory. Arc levels are controlled through a balance of induction and degradation in an activity-dependent manner. Arc further undergoes multiple post-translational modifications that regulate its stability, localization and function. Recent studies demonstrate that these features of Arc can be pharmacologically manipulated. In this review, we discuss some of these compounds, with an emphasis on drugs of abuse and psychotropic drugs. We also discuss inflammatory states that regulate Arc.

Keywords: Addiction; Antidepressants; Antipsychotics; Arc/Arg3.1; BDNF; Drugs of abuse; Inflammation.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
See this image and copyright information in PMC

References

    1. Alme M.N., et al. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast. 2007;2007:26496. doi: 10.1155/2007/26496. - DOI - PMC - PubMed
    1. Ammon S., et al. Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. Brain Res Mol Brain Res. 2003;112(1–2):113–125. doi: 10.1016/s0169-328x(03)00057-3. - DOI - PubMed
    1. Awad B.I., Carmody M.A., Steinmetz M.P. Potential role of growth factors in the management of spinal cord injury. World Neurosurg. 2015;83(1):120–131. doi: 10.1016/j.wneu.2013.01.042. - DOI - PubMed
    1. Balu D.T., Coyle J.T. Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. Neurochem. Int. 2014;75:76–78. doi: 10.1016/j.neuint.2014.05.015. - DOI - PMC - PubMed
    1. Barragan-Iglesias P., et al. bioRxiv; 2020. Intercellular Arc Signaling Regulates Vasodilation. 2020.08.13.250209. - DOI - PMC - PubMed

LinkOut - more resources