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Review
. 2021 Jan 30:2:100015.
doi: 10.1016/j.crphar.2021.100015. eCollection 2021.

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Buduru Gowthami  1 , S V Gopala Krishna  2 , D Subba Rao  3
Affiliations
Review

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Buduru Gowthami et al. Curr Res Pharmacol Drug Discov. .

Abstract

In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertension and rheumatoid arthritis, etc. They require prompt release of drug as per the disease condition, which can be achieved by programmed lag time. Chronotherapeutic drug delivery systems (CDDS) can be achieved by several methods, coating is one amongst them. Though the coating process is complex in terms of methodology, solubility issues and difficulty in achieving the uniform coating, many researchers were successfully employed in development of CDDS. A scientific prospection was made from 2010 to 2020 using PubMed database. Apart from exploration of publication data, we attempt to brief about classification of patents and concordance. The scrutiny also highlights the patents filed on chronotherapeutic systems, focusing particularly on coating technologies. The review is concluded the successful application of coating technology to develop CDDS, as evident from vast number of publications and patents filed.

Keywords: Chronotherapeutics; Coating; Patents; Scientific prospection.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Approaches and drugs required based on CDDSs.
Fig. 2
Fig. 2
Film coating method (adapted from the study by Kurakula et al., 2020) comprising (a) contact, (b) spreading and solvent evaporation, and (c) film formation with various types of wetting (LVI: liquid–vapor interface; SLI, solid–liquid interface; SVI: solid–vapor interface).
Fig. 3
Fig. 3
Cross section of a compression-coated tablet.
Fig. 4
Fig. 4
Numbers of publications that investigated chronotherapeutics and chronotherapeutics plus coatings.
Fig. 5
Fig. 5
Number of patent documents filed regarding chronotherapeutics during 2001–2020.
Fig. 6
Fig. 6
Number of patent documents filed regarding chronotherapeutics ​+ ​coating during 2001–2020.
Fig. 7
Fig. 7
Patents related to chronotherapeutics ​+ ​coating applications according to the US, IPCR, and CPC classifications.
Fig. 8
Fig. 8
Patent citations, publication dates, and jurisdictions.
See this image and copyright information in PMC

References

    1. Agarwal Vaibhav, Bansal Mayank. Design and optimization of a chronotherapeutic dosage form for treatment of nocturnal acid breakthrough. Curr Drug. 2012;9(6):608–616. doi: 10.2174/156720112803529756. - DOI - PubMed
    1. Agarwal Vaibhav, Bansal Mayank. Statistical optimization and fabrication of a press coated pulsatile dosage form to treat nocturnal acid breakthrough. Curr. Drug Deliv. 2013;10(4):444–452. doi: 10.2174/1567201811310040009. - DOI - PubMed
    1. Ali Javed, Baboota Sanjula, Ahuja Alka, Saigal Nitin. Distinctive features of “chronotherapeutic” and “pulsatile” drug delivery systems negating the practice of their interchangeable terminology. J. Drug Target. 2010;18(6):413–419. doi: 10.3109/10611861003587250. - DOI - PubMed
    1. Bi-Botti C. Youana chronopharmaceutical drug delivery systems: hurdles, hype or hope? Adv. Drug Deliv. Rev. 2010 July 31;62(9–10):898–903. doi: 10.1016/j.addr.2010.04.010. - DOI - PMC - PubMed
    1. Bruguerolle B., Labrecque G. Rhythmic pattern in pain and their chronotherapy. Adv. Drug Deliv. Rev. 2007;59(9–10):883–895. doi: 10.1016/j.addr.2006.06.001. - DOI - PubMed

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