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. 2021 Dec 8;36(11):e361105.
doi: 10.1590/ACB361105. eCollection 2021.

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

Mirkhalig Javadov  1 , Emrah Karatay  2 , Alev Cumbul  3 , Suleyman Orman  4 , Erhan Aysan  5
Affiliations

Effects of glycerol and sodium pentaborate containing new formulation on sleeve gastrectomy model in rats

Mirkhalig Javadov et al. Acta Cir Bras. .

Abstract

Purpose: The development of cutting surface leakage and postoperative peritoneal adhesions (PPA) after sleeve gastrectomy (SG) are the most serious operative complications. We investigated the effectiveness of the newly developed glycerol and sodium pentaborate containing formulation on the prevention of these complications.

Methods: Sixteen Sprague Dawley rats (mean weight 310 ± 50 g, mean age 3 months old) were divided into two groups, consisting of eight rats in each. SG and a double-layer suture technique were performed for each group. In study group, there was the mixture of 2 mL 3% glycerol plus 3% sodium pentaborate formulation, and in the control group 2 mL 0.9% NaCl was injected into the peritoneal cavity. Rats were sacrificed after 30 days, then macroscopic adhesion grade scoring and histopathological evaluations were assessed.

Results: Macroscopic PPA scores in the control and study groups were 2.75 ± 0.16 and 1.50 ± 0.327, respectively (p = 0.004). Histopatologic fibrosis scores in the control and study groups were 0.87 ± 0.125 and 2.00 ± 0.26, respectively (p = 0.002).

Conclusions: In SG operation model, glycerol plus sodium pentaborate compound decreased PPA formation and also increased stomach cut surface line fibrosis. This new formulation is hopeful for more safe SG operations.

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Conflict of interest statement

Conflict of interest: Nothing to declare.

Figures

Figure 1
Figure 1. Comparison of macroscopic PPA and histopathologic fibrosis scores of the groups.
Figure 2
Figure 2. Comparison of microscopic histopathologic fibrosis scores of the control and study groups.
See this image and copyright information in PMC

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