Current practice and evolving concepts in septic shock resuscitation

Jan Bakker^{1

2

3

4}, Eduardo Kattan⁴, Djillali Annane^{5

6}, Ricardo Castro⁴, Maurizio Cecconi^{7

8}, Daniel De Backer⁹, Arnaldo Dubin^{10

11}, Laura Evans¹², Michelle Ng Gong¹³, Olfa Hamzaoui¹⁴, Can Ince¹, Bruno Levy^{15

16

17}, Xavier Monnet¹⁸, Gustavo A Ospina Tascón¹⁹, Marlies Ostermann²⁰, Michael R Pinsky²¹, James A Russell²², Bernd Saugel²³, Thomas W L Scheeren²⁴, Jean-Louis Teboul²⁵, Antoine Vieillard Baron^{26

27}, Jean-Louis Vincent²⁸, Fernando G Zampieri^{29

30}, Glenn Hernandez³¹

Affiliations

¹ Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
² Department of Pulmonology and Critical Care, Columbia University Medical Center, New York, USA.
³ NYU School of Medicinel Langone, New York, USA.
⁴ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
⁵ Intensive Care Unit-AP-HP, Hôpital Raymond-Poincaré, Garches, France.
⁶ UFR des Sciences de la Santé Simone-Veil, Université de Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
⁷ Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy.
⁸ Department of Anesthesia and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
⁹ Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
¹⁰ Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
¹¹ Sanatorio Otamendi, Buenos Aires, Argentina.
¹² Department of Pulmonary and Critical Care Medicine, University of Washington, Seattle, USA.
¹³ Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
¹⁴ Service de Réanimation Polyvalente, Hôpital Antoine Béclère, AP-HP, Université Paris-Saclay, 92141, Clamart, France.
¹⁵ Service de Réanimation Médicale Brabois, CHRU Nancy, Pôle Cardio-Médico-Chirurgical, Vandoeuvre-les-Nancy, France.
¹⁶ INSERM U1116, Faculté de Médecine, Vandoeuvre-les-Nancy, France.
¹⁷ Université de Lorraine, Nancy, France.
¹⁸ Service de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Inserm UMR S_999, FHU SEPSIS, Groupe de Recherche Clinique CARMAS, Université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, France.
¹⁹ Department of Intensive Care Medicine Fundación Valle del Lili, Universidad ICESI, Cali, Colombia.
²⁰ Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, UK.
²¹ Department Bioengineering, Anesthesiology and Cardiovascular Diseases, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA.
²² Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada.
²³ Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁵ Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, AP-HP Université Paris-Saclay, Inserm UMR S_999, Le Kremlin-Bicêtre, France.
²⁶ Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.
²⁷ INSERM UMR 1018, Clinical Epidemiology Team, CESP, Paris-Saclay University, Villejuif, France.
²⁸ Dept of Intensive Care, Erasme Univ Hospital, Université Libre de Bruxelles, Brussels, Belgium.
²⁹ HCor Research Institute, São Paulo, Brazil.
³⁰ D'Or Research and Education Institute, São Paulo, Brazil.
³¹ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. glennguru@gmail.com.

PMID: 34910228
DOI: 10.1007/s00134-021-06595-9

Review

Current practice and evolving concepts in septic shock resuscitation

Jan Bakker et al. Intensive Care Med. 2022 Feb.

. 2022 Feb;48(2):148-163.

doi: 10.1007/s00134-021-06595-9. Epub 2021 Dec 15.

Authors

Affiliations

¹ Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
² Department of Pulmonology and Critical Care, Columbia University Medical Center, New York, USA.
³ NYU School of Medicinel Langone, New York, USA.
⁴ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
⁵ Intensive Care Unit-AP-HP, Hôpital Raymond-Poincaré, Garches, France.
⁶ UFR des Sciences de la Santé Simone-Veil, Université de Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
⁷ Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy.
⁸ Department of Anesthesia and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
⁹ Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
¹⁰ Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
¹¹ Sanatorio Otamendi, Buenos Aires, Argentina.
¹² Department of Pulmonary and Critical Care Medicine, University of Washington, Seattle, USA.
¹³ Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
¹⁴ Service de Réanimation Polyvalente, Hôpital Antoine Béclère, AP-HP, Université Paris-Saclay, 92141, Clamart, France.
¹⁵ Service de Réanimation Médicale Brabois, CHRU Nancy, Pôle Cardio-Médico-Chirurgical, Vandoeuvre-les-Nancy, France.
¹⁶ INSERM U1116, Faculté de Médecine, Vandoeuvre-les-Nancy, France.
¹⁷ Université de Lorraine, Nancy, France.
¹⁸ Service de médecine intensive-réanimation, Hôpital de Bicêtre, DMU CORREVE, Inserm UMR S_999, FHU SEPSIS, Groupe de Recherche Clinique CARMAS, Université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, France.
¹⁹ Department of Intensive Care Medicine Fundación Valle del Lili, Universidad ICESI, Cali, Colombia.
²⁰ Department of Critical Care, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, UK.
²¹ Department Bioengineering, Anesthesiology and Cardiovascular Diseases, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA.
²² Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada.
²³ Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
²⁴ Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁵ Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, AP-HP Université Paris-Saclay, Inserm UMR S_999, Le Kremlin-Bicêtre, France.
²⁶ Medical Intensive Care Unit, Ambroise Paré Hospital, AP-HP, Boulogne-Billancourt, France.
²⁷ INSERM UMR 1018, Clinical Epidemiology Team, CESP, Paris-Saclay University, Villejuif, France.
²⁸ Dept of Intensive Care, Erasme Univ Hospital, Université Libre de Bruxelles, Brussels, Belgium.
²⁹ HCor Research Institute, São Paulo, Brazil.
³⁰ D'Or Research and Education Institute, São Paulo, Brazil.
³¹ Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. glennguru@gmail.com.

PMID: 34910228
DOI: 10.1007/s00134-021-06595-9

Abstract

Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.

Keywords: Fluid resuscitation; Fluids; Intensive care; Sepsis; Treatment; Vasoactive drugs.

PubMed Disclaimer

References

1. Menk M, Estenssoro E, Sahetya SK, Neto AS, Sinha P, Slutsky AS, Summers C, Yoshida T, Bein T, Ferguson ND (2020) Current and evolving standards of care for patients with ARDS. Intensive Care Med 46:2157–2167 - PubMed - PMC - DOI
1. Vincent JL, Joosten A, Saugel B (2021) Hemodynamic monitoring and support. Crit Care Med 49:1638–1650 - PubMed - DOI
1. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, Machado FR, McIntyre L, Ostermann M, Prescott HC, Schorr C, Simpson S, Wiersinga WJ, Alshamsi F, Angus DC, Arabi Y, Azevedo L, Beale R, Beilman G, Belley-Cote E, Burry L, Cecconi M, Centofanti J, Coz Yataco A, De Waele J, Dellinger RP, Doi K, Du B, Estenssoro E, Ferrer R, Gomersall C, Hodgson C, Moller MH, Iwashyna T, Jacob S, Kleinpell R, Klompas M, Koh Y, Kumar A, Kwizera A, Lobo S, Masur H, McGloughlin S, Mehta S, Mehta Y, Mer M, Nunnally M, Oczkowski S, Osborn T, Papathanassoglou E, Perner A, Puskarich M, Roberts J, Schweickert W, Seckel M, Sevransky J, Sprung CL, Welte T, Zimmerman J, Levy M (2021) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 47:1181–1247 - PubMed - PMC - DOI
1. Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, Jaeschke R, Mebazaa A, Pinsky MR, Teboul JL, Vincent JL, Rhodes A (2014) Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 40:1795–1815 - PubMed - PMC - DOI
1. Jansen TC, van Bommel J, Schoonderbeek FJ, Visser SJS, van der Klooster JM, Lima AP, Willemsen SP, Bakker J, Grp LS (2010) Early lactate-guided therapy in intensive care unit patients a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 182:752–761 - PubMed - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- ClinicalTrials.gov

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Current practice and evolving concepts in septic shock resuscitation

Affiliations

Current practice and evolving concepts in septic shock resuscitation

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical