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. 2022 Feb;51(2):146-151.
doi: 10.1111/jop.13269. Epub 2021 Dec 31.

Oral versus extra-oral plasmablastic lymphoma: A comparative analysis of 101 cases

Shabnum Meer  1 , Yvonne Perner  2 , Pascale Willem  3
Affiliations

Oral versus extra-oral plasmablastic lymphoma: A comparative analysis of 101 cases

Shabnum Meer et al. J Oral Pathol Med. 2022 Feb.

Abstract

Aims: Originally described exclusively orally in HIV-infected patients, plasmablastic lymphoma (PBL) is increasingly described extra orally and in non-HIV-infected persons. The study comparatively analysed the clinico-pathologic features of oral PBLs (n = 55) to previously published extra-oral PBLs (n = 45 + 1) diagnosed over a seven-year period at the same institution in an HIV prevalent setting in South Africa in order to clarify any distinction between oral and extra-oral PBLs.

Methods and results: Tumours were assessed histologically and immunohistochemically with CD45 (LCA), CD3, CD20, CD79a, PAX5, CD138, MUM1, BLIMP1, VS38c, Ki-67, BCL6 and CD10 using standard protocols. Age ranged from 22 to 76 years (oral) and 9 and 59 years (extra-oral). Most PBL patients were HIV positive [oral (84%); extra-oral (65%)]. Male:female ratio was 2.7:1 for oral and 1.4:1 for extra-oral PBLs. Favoured oral and extra-oral sites were the maxilla and anus. PBLs displayed an indistinguishable immunohistochemical profile with unusually high CD45 expression (oral: 98%, extra-oral: 84%). EBV assessed by chromogenic in situ hybridisation (ISH) showed positivity in all oral PBLs and 95% extra-oral PBLs. MYC rearrangements (fluorescence ISH MYC break-apart probe) were similar in all the PBLs.

Conclusions: Extra-oral PBL is identical to its oral counterpart in gender and age distribution, HIV status, morphological appearances, immunophenotypic profile and EBV association. PBL should be regarded as the same tumour irrespective of oral or extra-oral site of origin.

Keywords: MYC; EBV; HIV; extra-oral; oral; plasmablastic lymphoma.

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References

REFERENCES

    1. Delecluse HJ, Anagnostopoulos I, Dallenbach F, et al. Plasmablastic lymphomas of the oral cavity: a new entity associated with the human immunodeficiency virus infection. Blood. 1997;89:1413-1420.
    1. Lopez A, Abrisqueta P. Plasmablastic lymphoma: current perspectives. Blood Lymphat Cancer. 2018;8:63-70.
    1. Meer S, Perner Y, McAlpine ED, Willem P. Extraoral plasmablastic lymphoma in a high human immunodeficiency virus endemic area. Histopathology. 2020;76:212-221.
    1. Liu Z, Filip I, Gomez K, et al. Genomic characterization of HIV-associated plasmablastic lymphoma identifies pervasive mutations in the JAK-STAT pathway. Blood Cancer Discov. 2020;1:112-125.
    1. Alli N, Meer S. Head and neck lymphomas: a 20-year review in an Oral Pathology Unit, Johannesburg, South Africa, a country with the highest global incidence of HIV/AIDS. Oral Oncol. 2017;67:17-23.

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