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. 2022 Jan;33(1):e10.
doi: 10.3802/jgo.2022.33.e10. Epub 2021 Nov 12.

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Giorgio Bogani  1 , Giovanni Scambia  2 , Chiara Cimmino  3 , Francesco Fanfani  2 , Barbara Costantini  2 , Matteo Loverro  2 , Gabriella Ferrandina  2 , Fabio Landoni  4 , Luca Bazzurini  4 , Tommaso Grassi  4 , Domenico Vitobello  5 , Gabriele Siesto  5 , Anna Myriam Perrone  6 , Vanna Zanagnolo  7 , Pierandrea De Iaco  6 , Francesco Multinu  7 , Fabio Ghezzi  8 , Jvan Casarin  8 , Roberto Berretta  9 , Vito A Capozzi  9 , Errico Zupi  10 , Gabriele Centini  10 , Antonio Pellegrino  11 , Silvia Corso  11 , Guido Stevenazzi  12 , Serena Montoli  12 , Anna Chiara Boschi  13 , Giuseppe Comerci  13 , Pantaleo Greco  14 , Ruby Martinello  14 , Francesco Sopracordevole  15 , Giorgio Giorda  15 , Tommaso Simoncini  16 , Marta Caretto  16 , Enrico Sartori  17 , Federico Ferrari  17 , Antonio Cianci  18 , Giuseppe Sarpietro  18 , Maria Grazia Matarazzo  18 , Fulvio Zullo  19 , Giuseppe Bifulco  19 , Michele Morelli  20 , Annamaria Ferrero  21 , Nicoletta Biglia  21 , Fabio Barra  22 , Simone Ferrero  22 , Umberto Leone Roberti Maggiore  23 , Stefano Cianci  24 , Vito Chiantera  25 , Alfredo Ercoli  24 , Giulio Sozzi  25 , Angela Martoccia  26 , Sergio Schettini  26 , Teresa Orlando  26 , Francesco G Cannone  27 , Giuseppe Ettore  27 , Andrea Puppo  28 , Martina Borghese  28 , Canio Martinelli  24 , Ludovico Muzii  29 , Violante Di Donato  29 , Lorenza Driul  30 , Stefano Restaino  30 , Alice Bergamini  31 , Giorgio Candotti  31 , Luca Bocciolone  31 , Francesco Plotti  32 , Roberto Angioli  32 , Giulia Mantovani  33 , Marcello Ceccaroni  33 , Chiara Cassani  34 , Mattia Dominoni  34 , Laura Giambanco  35 , Silvia Amodeo  35 , Livio Leo  36 , Raphael Thomasset  36 , Diego Raimondo  37 , Renato Seracchioli  37 , Mario Malzoni  38 , Franco Gorlero  39 , Martina Di Luca  39 , Enrico Busato  40 , Sami Kilzie  40 , Andrea Dell'Acqua  41 , Giovanna Scarfone  41 , Paolo Vercellini  41 , Marco Petrillo  42 , Salvatore Dessole  42 , Giampiero Capobianco  42 , Andrea Ciavattini  43 , Giovanni Delli Carpini  43 , Luca Giannella  43 , Liliana Mereu  44 , Saverio Tateo  44 , Flavia Sorbi  45 , Massimiliano Fambrini  45 , Stefania Cicogna  46 , Federico Romano  46 , Giuseppe Ricci  46   47 , Giuseppe Trojano  48 , Roberto Consonni  49 , Simona Cantaluppi  49 , Antonio Lippolis  50 , Raffaele Tinelli  50 , Giovanni D'Ippolito  51 , Lorenzo Aguzzoli  51 , Vincenzo D Mandato  51 , Stefano Palomba  52 , Davide Calandra  53 , Maurizio Rosati  53   54 , Cinzia Gallo  55 , Daniela Surico  56 , Valentino Remorgida  56 , Francesco Ruscitto  57 , Paolo Beretta  57 , Pierluigi Benedetti Panici  29 , Francesco Raspagliesi  23
Affiliations

Characteristics and patterns of care of endometrial cancer before and during COVID-19 pandemic

Giorgio Bogani et al. J Gynecol Oncol. 2022 Jan.

Abstract

Objective: Coronavirus disease 2019 (COVID-19) outbreak has correlated with the disruption of screening activities and diagnostic assessments. Endometrial cancer (EC) is one of the most common gynecological malignancies and it is often detected at an early stage, because it frequently produces symptoms. Here, we aim to investigate the impact of COVID-19 outbreak on patterns of presentation and treatment of EC patients.

Methods: This is a retrospective study involving 54 centers in Italy. We evaluated patterns of presentation and treatment of EC patients before (period 1: March 1, 2019 to February 29, 2020) and during (period 2: April 1, 2020 to March 31, 2021) the COVID-19 outbreak.

Results: Medical records of 5,164 EC patients have been retrieved: 2,718 and 2,446 women treated in period 1 and period 2, respectively. Surgery was the mainstay of treatment in both periods (p=0.356). Nodal assessment was omitted in 689 (27.3%) and 484 (21.2%) patients treated in period 1 and 2, respectively (p<0.001). While, the prevalence of patients undergoing sentinel node mapping (with or without backup lymphadenectomy) has increased during the COVID-19 pandemic (46.7% in period 1 vs. 52.8% in period 2; p<0.001). Overall, 1,280 (50.4%) and 1,021 (44.7%) patients had no adjuvant therapy in period 1 and 2, respectively (p<0.001). Adjuvant therapy use has increased during COVID-19 pandemic (p<0.001).

Conclusion: Our data suggest that the COVID-19 pandemic had a significant impact on the characteristics and patterns of care of EC patients. These findings highlight the need to implement healthcare services during the pandemic.

Keywords: COVID-19; Endometrial Cancer; SARS-CoV-2; Uterine cancer.

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Conflict of interest statement

The first author is a principal editor of the Journal of Gynecologic Oncology. No other potential conflict of interest relevant to this article was reported

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