Task-induced modulations of neuronal activity along the auditory pathway

Abstract

Sensory processing varies depending on behavioral context. Here, we ask how task engagement modulates neurons in the auditory system. We train mice in a simple tone-detection task and compare their neuronal activity during passive hearing and active listening. Electrophysiological extracellular recordings in the inferior colliculus, medial geniculate body, primary auditory cortex, and anterior auditory field reveal widespread modulations across all regions and cortical layers and in both putative regular- and fast-spiking cortical neurons. Clustering analysis unveils ten distinct modulation patterns that can either enhance or suppress neuronal activity. Task engagement changes the tone-onset response in most neurons. Such modulations first emerge in subcortical areas, ruling out cortical feedback as the only mechanism underlying subcortical modulations. Half the neurons additionally display late modulations associated with licking, arousal, or reward. Our results reveal the presence of functionally distinct subclasses of neurons, differentially sensitive to specific task-related variables but anatomically distributed along the auditory pathway.

Keywords: arousal; attention; auditory cortex; electrophysiology; inferior colliculus; medial geniculate body; mouse; reward; sensory perception; task engagement.