Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy
- PMID: 34911145
- PMCID: PMC9302692
- DOI: 10.1002/chem.202104078
Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy
Abstract
N-Acyliminium ions are highly reactive intermediates that are important for creating CC-bonds adjacent to nitrogen atoms. Here we report the characterization of cyclic N-acyliminium ions in the gas phase, generated by collision induced dissociation tandem mass spectrometry followed by infrared ion spectroscopy using the FELIX infrared free electron laser. Comparison of DFT calculated spectra with the experimentally observed IR spectra provided valuable insights in the conformations of the N-acyliminium ions.
Keywords: DFT calculations; N-acyliminium ion; heterocycles; ion spectroscopy; stereoselectivity.
© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- None
-
- Royer J., Bonin M., Micouin L., Chem. Rev. 2004, 104, 2311–2352; - PubMed
-
- Maryanoff B. E., Zhang H.-C., Cohen J. H., Turchi I. J., Maryanoff C. A., Chem. Rev. 2004, 104, 1431–1628; - PubMed
-
- Speckamp W. N., Moolenaar M. J., Tetrahedron 2000, 56, 3817–3856;
-
- Xu Z., Wang Q., Zhu J., J. Am. Chem. Soc. 2015, 137, 6712–6724; - PubMed
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